慢性心力衰竭合并肌肉衰减综合征的研究进展

Progress of chronic heart failure complicated with sarcopenia

肌肉衰减综合征是一种与年龄增长相关,以进行性全身骨骼肌质量减少、肌肉强度下降和肌肉功能减退为主要特征的临床综合征。慢性心力衰竭是心血管疾病中影响患者生存率的重要疾病之一。越来越多的研究发现慢性心力衰竭可能造成或加重肌肉衰减综合征的进展,其机制涉及营养不良、运动量下降、炎症反应、氧化应激及激素变化等。目前的治疗策略主要包括运动干预、营养支持和药物治疗。本文就近年慢性心力衰竭合并肌肉衰减综合征的发病机制及治疗方案等方面的研究进展进行综述。

Sarcopenia is an age-dependent progressive and generalised skeletal muscle disorder,mainly characterized by loss of skeletal muscle mass,reduced muscle strength,and impaired functional capacity.Chronic heart failure is one of the important diseases that affect the survival rate of patients in cardiovascular diseases.More and more evidence shows that chronic heart failure may cause or exacerbate sarcopenia,and the mechanism involved are malnutrition,decreased physical activity,inflammatory response,oxidative stress and hormonal changes.Current treatment strategies mainly include exercise intervention,nutritional support and drug therapy.This paper reviews the progress in the pathogenesis,mechanism and treatment regimens for chronic heart failure patients complicated with sarcopenia in recent years.