盘龙七片联合洛索洛芬钠对膝骨关节炎患者滑液BMP-2、COMP表达及Lysholm评分的影响

The influence of panlongqi tablets combined with loxoprofen sodium tablets on BMP-2 and COMP expression in synovial fluid and Lysholm score in patients with knee osteoarthritis

目的 研究盘龙七片联合洛索洛芬钠对膝骨关节炎患者滑液骨形态发生蛋白-2(BMP-2)、软骨寡聚基质蛋白(COMP)表达及Lysholm评分的影响。方法 选择2019年9月—2022年1月本院收治的150例膝骨关节炎患者作为研究对象,采用随机数表法分为实验组和对照组两组,每组各75例。对照组给予常规洛索洛芬钠治疗,实验组在对照组基础上给予盘龙七片治疗。对比两组患者治疗前后滑液BMP-2、COMP水平、Lysholm评分以及炎性因子水平[白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)];对比两组患者临床疗效;对比两组患者治疗期间出现的不良反应。结果 治疗后,两组患者滑液BMP-2、COMP水平均显著低于治疗前,且实验组滑液BMP-2、COMP水平更低(P<0.05);治疗后,两组患者Lysholm评分水平均显著高于治疗前,且实验组Lysholm评分有所更高(P<0.05);治疗后,两组患者滑液L-6、TNF-α水平均低于治疗前,且实验组滑液L-6、TNF-α更低(P<0.05);实验组患者临床总有效率为93.33%(70/75),高于对照组的82.66%(62/75)(P<0.05);实验组患者不良反应发生率为6.64%(5/75),与对照组的5.33%(4/75)相比差异无统计学意义(P>0.05)。结论 对于膝骨关节炎患者,在洛索洛芬钠基础上联合盘龙七片,对患者滑液BMP-2、COMP以及Lysholm评分的改善更为明显。

Objective To investigate the effects of Panlongqi tablets combined with loxoprofen sodium tablets on bone morphogenetic protein-2(BMP-2) and cartilage oligomeric matrix protein(COMP) expression in synovial fluid and Lysholm score in patients with knee osteoarthritis. Methods One hundred and fifty patients suffered with knee osteoarthritis those were admitted to our hospital from September 2020 to December 2021 were enrolled in the study, and they were divided into two groups via random number table methods, each with 75 cases. Patients in control group received loxoprofen sodium tablets, based on this, experimental group received Panlongqi tablets in addition. Before and after the treatment, BMP-2 and COMP expression levels in synovial fluid, Lysholm score and serum levels of inflammation factors [interleukin(IL-6) and tumor necrosis factor-α(TNF-α)]were compared between the two groups. Comparison was also conducted on the clinical efficacy and adverse reactions.Results Expression of BMP-2 and COMP in synovial fluid were significantly down-regulated in two groups after treatment, and the expression was significantly lower in experimental group than in control group(P<0.05). An increase was found in Lysholm score in both groups after treatment, and the score of experimental group was obviously higher than that of control group(P<0.05). A significant decrease was found in serum levels of IL-6 and TNF-α in both groups after treatment, and the decrease was more remarkable in experimental group than in control group(P<0.05). The total efficacy rate was 93.33%(70/75) in experimental group, which was higher than 82.66%(62/75) in control group(P<0.05). The adverse reaction rate was 6.64%(5/75) in experimental group, which had no significant difference compared with 5.33%(4/75) in control group(P>0.05). Conclusions Application of loxoprofen sodium tablets in combination with Panlongqi tablets in the treatment of knee osteoarthritis could effectively ameliorate the BMP-2 and COMP expression in synovial fluid and Lysholm score in patients.