摘要
During mitosis,the allocation of genetic material concurs with organelle transformation and distribution.The coordination of genetic material inheritance with organelle dynamics directs accurate mitotic progression,cell fate determination,and organismal homeostasis.Small GTPases belonging to the Ras superfamily regulate various cell organelles during division.Being the key regulators of membrane dynamics,the dysregulation of small GTPases is widely associated with cell organelle disruption in neoplastic and non-neoplastic diseases,such as cancer and Alzheimer’s disease.Recent discoveries shed light on the molecular properties of small GTPases as sophisticated modulators of a remarkably complex and perfect adaptors for rapid structure reformation.This review collects current knowledge on small GTPases in the regulation of cell organelles during mitosis and highlights the mediator role of small GTPase in transducing cell cycle signaling to organelle dynamics during mitosis.
基金
supported by the National Kcy R&D Program of China(Nos.2019YFA0110300 and 2017YFA0505600-04)
the National Natural Science Foundation of China(Nos.81820108024 and 81630005)
the Innovative Research Team in University of Ministry of Edueation of China(No.IRT-17R15)
and the Natural Science Foundation of Guangdong(Nos.2016A030311038 and 2017A030313608).
