摘要
在COVID-19爆发两年后,越来越多的COVID-19患者被“Long COVID”(LC)症状困扰。LC指COVID-19患者在最初症状出现后的四周后持续出现的症状、和/或延迟出现的长期并发症。持续疲劳是LC最常见的症状之一,严重降低患者的生活质量。被称为“中药之王”的人参在临床上具有抗疲劳作用。在这篇综述中,我们总结了人参提取物及其活性化合物的潜在抗疲劳机制,特别关注其在抗病毒、免疫重塑、内分泌系统调节和代谢方面的作用,提出人参是治疗LC特别是缓解疲劳症状的可行方案。
Two years after the coronavirus disease 2019(COVID-19)outbreak,an increasing number of patients continue to suffer from long COVID(LC),persistent symptoms,and/or delayed or long-term complications beyond the initial 4 weeks from the onset of symptoms.Constant fatigue is one of the most common LC symptoms,leading to severely reduced quality of life among patients.Ginseng Radix et Rhizoma—known as the King of Herbs in traditional Chinese medicine—has shown clinical anti-fatigue effects.In this review,we summarize the underlying anti-fatigue mechanisms of Ginseng Radix et Rhizoma extracts and their bioactive compounds,with a special focus on anti-viral,immune remodeling,endocrine system regulation,and metabolism,suggesting that Ginseng Radix et Rhizoma is a potentially promising treatment for LC,especially regarding targeting fatigue.
作者
周翔达
张可滢
刘览博
赵倩茹
黄明
邵瑞
王炎炎
屈彬
王彧
Xiangda Zhou;Keying Zhang;Lanbo Liu;Qianru Zhao;Ming Huang;Rui Shao;Yanyan Wang;Bin Qu;Yu Wang(Department of Biophysics,Center for Integrative Physiology and Molecular Medicine(CIPMM),School of Medicine,Saarland University,Homburg,Germany;School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin,China;School of Integrative Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,China;Leibniz Institute for New Materials,Saarbrucken,Germany)
基金
funded by the Science&Technology Development Fund of the Tianjin Education Commission for Higher Education(2018KJ010)。
关键词
疲劳
人参
长期新冠肺炎
新冠病毒病
Fatigue
Ginseng Radix et Rhizoma
Long COVID
SARS-CoV-2
