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PI3K/AKT/mTOR信号通路及细胞周期蛋白在头颈部HPV相关鳞癌中表达分析 被引量:1

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摘要 目的研究PI3K/AKT/mTOR信号通路及细胞周期蛋白在头颈部人乳头瘤病毒(HPV)相关鳞癌中表达.方法选择头颈部鳞癌组织40例,其中HPV相关鳞癌20例,非HPV相关鳞癌20例,同时以20例正常鳞状上皮为对照组,免疫组化检测癌组织与正常组织PI3K、AKT、mTOR、细胞周期蛋白cyclin D1、cyclin B1、cyclin E表达.结果20例HPV相关鳞癌组织中PI3K、AKT、mTOR、cyclin D1、cyclin B1、cyclin E蛋白表达明显高于正常鳞状上皮组织(P<0.01);与非HPV相关鳞癌相比,HPV相关鳞癌组织中蛋白表达增加(P<0.01).结论头颈部HPV相关鳞癌中PI3K/AKT/mTOR信号通路激活,细胞周期蛋白cyclin D1、cyclin B1、cyclin E蛋白表达增加,表明PI3K/AKT/mTOR通路通过细胞周期蛋白参与鳞癌的发病过程,可能为治疗的靶点之一.
出处 《福建医药杂志》 CAS 2022年第4期123-126,共4页 Fujian Medical Journal
基金 宁波市医学科技计划项目(2018A28)。
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