老年急性加重期慢阻肺患者血清TNF-α、HDAC2及PTX3的动态变化

Dynamic changes of serum TNF-α,HDAC2,and PTX3 in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

目的探讨老年急性加重期慢阻肺患者血清肿瘤坏死因子-α、乙酰化酶2及正五聚蛋白3的动态变化及临床意义。方法选择2020年1月至2021年8月期间于我院住院的老年急性加重期慢阻肺患者及同期健康体检者作为研究对象,急性加重期慢阻肺根据预后情况分为存活组和死亡组。检测全部研究对象的第1天、第3~5天和第7~9天的TNF-α、HDAC2及PTX3水平并分析。结果(1)急性加重期组患者的TNF-α、PTX3水平高于健康组,而HDAC2则低于健康组(P<0.05)。(2)健康组患者第1天、第3~5天及第7~9天的TNF-α、HDAC2及PTX3趋于稳定,急性加重期组患者的TNF-α和PTX3皆总体呈下降趋势,而HDAC2则总体呈上升趋势(P<0.05)。(3)急性加重期存活组和死亡组患者的TNF-α和PTX3皆总体呈下降趋势,而HDAC2则总体呈上升趋势,死亡组患者的第1天、第3~5天及第7~9天的TNF-α和PTX3皆高于存活组,而HDAC2则皆低于存活组(P<0.05)。结论老年急性加重期慢阻肺患者TNF-α、HDAC2及PTX3失衡比较明显,血清TNF-α、HDAC2及PTX3可用于急性加重期慢阻肺的诊断。

Objective To investigate the dynamic changes and clinical significance of serum tumor necrosis factor-α(TNF-α),histone deacetylase 2(HDAC2),and pentraxin 3(PTX3)in elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Elderly patients with AECOPD who were hospitalized in our hospital from January 2020 to August 2021 and the healthy subjects during the same period were selected as the research subjects.Patients with AECOPD were divided into the survival group and the death group according to the prognosis.The levels of TNF-α,HDAC2 and PTX3 were detected and analyzed on the 1st day,the 3rd to the 5th day and the 7th to the 9th day of all the subjects.Results(1)The levels of TNF-αand PTX3 in the AECOPD group were higher than those in the healthy group,but HDAC2 was lower than that in the healthy group(P<0.05).(2)The levels of TNF-α,HDAC2,and PTX3 in the healthy group tended to be stable on the 1st day,the 3rd to the 5th day and the 7th to the 9th day.The overall trend showed an upward trend(P<0.05).(3)In the acute exacerbation period,TNF-αand PTX3 levels were generally decreased in the survival group and the death group,while HDAC2 showed an overall upward trend.TNF-αand PTX3 in the death group were higher than those in the survival group on day 1,3 to 5 and 7 to 9,while HDAC2 were lower than those in the survival group(P<0.05).Conclusion The imbalance of TNF-α,HDAC2 and PTX3 is obvious in in elderly patients with AECOPD,and serum TNF-α,HDAC2,and PTX3 can be used for the diagnosis of AECOPD.