摘要
Capsule shells have been successfully fabricated from water-soluble chitosan(WSC)with the addition of alginate and Gembili starch.WSC was synthesized from crab shell chitosan by depolymerization reaction.The capsule shells were made with the composition of WSC:Alginate,2:1,3:1 and 4:1(w/w)with and without the addition of Gembili starch.Gembili starch was added with a ratio of Alginate:Starch,1:1(w/w).The capsule shell properties were evaluated according to Indonesian Pharmacopoeia standard.The solubility test showed that the capsule shells were comply with the standard.The highest degrees of swelling in water and HCl 0.1 N solution were 491.93%and 410.51%,respectively.The highest degradation percentages in water and HCl 0.1 N solution were 57.80%and 21.44%,respectively.The observation of physical appearance indicated that the capsule shell with WSC:Alginate:Starch in ratio of 3:1:1 has appearance close to commercial capsule shell.
