c-Met及MACC1在甲状腺乳头状癌中的表达及临床意义

Expression and Clinical Significance of c-Met and MACC1 in Papillary Thyroid Carcinoma

目的探讨肝细胞生长因子受体(c-Met)与结肠癌转移相关基因(MACC1)在甲状腺乳头状癌中的表达,及其与甲状腺乳头状癌临床病理特征的关系。方法采用免疫组织化学染色法检测60例甲状腺乳头状癌组织及30例良性甲状腺组织(甲状腺腺瘤15例,结节性甲状腺肿15例)中c-Met及MACC1的表达情况,并结合临床病理特征进行相关分析。结果c-Met及MACC1蛋白在甲状腺乳头状癌中的阳性表达率均高于良性甲状腺疾病,差异有统计学意义(P<0.05);Spearman相关性检验结果表明c-Met与MACC1蛋白在甲状腺乳头状癌中的表达呈正相关(r=0.394,P<0.05);MACC1蛋白在有无淋巴结转移的甲状腺乳头状癌的阳性表达率比较,差异有统计学意义(P<0.05);而不同年龄、性别、肿块大小c-Met蛋白及MACC1蛋白阳性表达率比较,差异无统计学意义(P>0.05);c-Met蛋白在有无淋巴结转移的甲状腺乳头状癌的阳性表达率比较,差异无统计学意义(P>0.05)。结论MACC1及c-Met蛋白可能参与了甲状腺乳头状癌的发生发展过程,并可能对甲状腺乳头状癌的诊断及靶向治疗提供思路。

Objective To investigate the expression of c-metprotoncogene(c-Met)and colon cancer metastasis-related gene(MACC1)in papillary thyroid carcinoma and its relationship with clinicopathological features of papillary thyroid carcinoma.Methods Immunohistochemical staining was used to detect the expression of c-Met and MACC1 in 60 cases of papillary thyroid carcinoma and 30 cases of benign thyroid tissues(15 cases of thyroid adenoma and 15 cases of nodular goiter),and correlation analysis was carried out combined with clinical pathological features.Results The positive expression rates of c-Met and MACC1 protein in papillary thyroid carcinoma were higher than those in benign thyroid diseases,and the difference was statistically significant(P<0.05).Spearman correlation test showed that the expression of c-Met and MACC1 protein in papillary thyroid carcinoma was positively correlated(r=0.394,P<0.05).The positive expression rate of MACC1 protein in papillary thyroid carcinoma with or without lymph node metastasis was statistically significant(P<0.05);while there was no significant difference in the positive expression rate of c-Met protein and MACC1 protein in different age,gender,tumor size(P>0.05).There was no significant difference in the positive expression rate of c-Met protein in papillary thyroid carcinoma with or without lymph node metastasis(P>0.05).Conclusion MACC1 and c-Met protein may be involved in the occurrence and development of papillary thyroid carcinoma,and may provide ideas for the diagnosis and targeted therapy of papillary thyroid carcinoma.