平滑肌细胞衰老在肺动脉高压中的作用

The role of smooth muscle cell senescence in pulmonary hypertension

肺动脉高压(PAH)是一种恶性心血管疾病,肺动脉中膜增厚是PAH的一个公认特征,平滑肌细胞在中膜增厚中起重要作用。衰老细胞随年龄积累,最终导致机体老化以及年龄相关性疾病。近年来,基础和临床研究均发现衰老的肺动脉平滑肌细胞(PASMCs)具有代谢活性,并显示出与该状态相关的特征性形态和生理变化,如具有扩大的扁平形状,β-半乳糖苷酶积聚,衰老相关的分泌型表型等,参与PAH的发生发展。本文就PASMCs衰老的相关标志物及衰老PASMCs诱发PAH的发生发展机制进行综述,为防治PAH提供新的研究思路。

Pulmonary arterial hypertension(PAH)is a kind of malignant cardiovascular disease.Pulmonary artery media thickening is a recognized feature of pulmonary arterial hypertension.Smooth muscle cells are generally believed to play an important role in the media thickening.Senescent cells accumulate with age,eventually leading to aging and age-related diseases.In recent years,both basic and clinical studies have found that senescent pulmonary smooth muscle cells(PASMCs)exhibit metabolic activity and characteristic morphological and physiological changes associated with this state,such as enlarged flat shape,β-galactosidase accumulation,and senescence related secretory phenotype,which are involved in the development of PAH.In this paper,the related markers of PASMCs senescence and the pathogenesis of PASMCs-induced PAH were reviewed,providing new research ideas for the prevention and treatment of PAH.