卡培他滨致不良反应文献分析

Literature analysis of adverse reactions induced by capecitabine

目的探讨卡培他滨不良反应发生的特点及规律,为临床合理用药提供参考。方法将“卡培他滨”、“不良反应”作为检索词,对2000年1月~2021年7月中国期刊全文数据库、维普中文科技期刊数据库、万方数据库公开报道的卡培他滨ADR的个案文献报道进行分析。结果筛选到文献15篇,案例19例,其中男9例(47.37%),女10例(52.63%);年龄以50岁以上患者居多(15例,占比78.95%);ADR多发生在用药4周期以内居多(15例,占比78.95%);累及系统-器官以皮肤和皮下组织系统和胃肠道系统为主,均为14例;临床主要表现为手足综合征(11例)和骨髓抑制(6例)等;经对症处理后,18例患者好转,1例患者死亡。结论在使用卡培他滨用于化疗时,应注意个体化用药剂量,当与其他化疗药联合用药时更应加强药学监护。

Objective To investigate the characteristics and regularity of ADR of capecitabine,and to provide reference for clinical rational medication.Methods"Capecitabine"and"adverse reactions"were used as search terms to analyze the case literature reports of capecitabine ADR publicly reported by China Journal Full-text Database,VIP Chinese Science and Technology Journal Database and Wanfang Database from January 2000 to July 2021.Results Fifteen literatures were screened,including 19 cases,including 9 males(47.37%)and 10 females(52.63%).Most patients were over 50 years old(15 cases,accounting for 78.95%).Most ADR occurred within 4 cycles(15 cases,accounting for 78.95%).Skin and subcutaneous tissue system and gastrointestinal system were the main systems/organs involved,accounting for 14 cases.The main clinical manifestations were hand-foot syndrome(11 cases)and bone marrow suppression(6 cases).After symptomatic treatment,18 patients improved and 1 patient died.Conclusion Individual dosage should be paid attention to when capecitabine is used for chemotherapy,and pharmaceutical care should be strengthened when capecitabine is used in combination with other chemotherapy drugs.