法舒地尔和硝酸异山梨酯治疗急性冠脉综合征低危患者的疗效比较

Comparison of the efficacy of fasudil and isosorbide dinitrate in the treatment of low-risk patients with acute coronary syndrome

目的分析急性冠脉综合征低危患者采用不同药物治疗的价值。方法选取2020年2月~2021年8月收治的78例急性冠脉综合征低危患者作为研究对象,按随机数字表法分为两组,每组39例,对照组采用硝酸异山梨酯治疗,观察组采用法舒地尔治疗,对比两组临床疗效、不良事件发生率、临床指标、TFC值。结果观察组临床疗效(94.87%)高于对照组(76.92%)(χ^(2)=4.152,P<0.05);观察组不良事件发生率(7.69%)低于对照组(25.64%)差异有统计学意义(χ^(2)=4.523,P<0.05);观察组LVEF、NO高于对照组,BNP、NE、CRP低于对照组,差异均有统计学意义(t=11.051、6.239、13.671、7.771、67.147,P<0.05);观察组右冠状动脉、左回旋支、左前降支TFC值低于对照组,差异均有统计学意义(t=7.293、9.591、7.519,P<0.05)。结论选择法舒地尔对急性冠脉综合征低危患者进行治疗,可改善其心功能及血管内皮功能,降低不良事件发生率。

Objective To analyze the value of different medications for low-risk patients with acute coronary syndrome.Methods A total of 78 low-risk patients with acute coronary syndromes admitted from February 2020 to August 2021 were selected as the research objects.They were divided into two groups according to the random number table method,with 39 cases in each group.The control group was treated with isosorbide dinitrate.The observation group was treated with fasudil.And the clinical efficacy,incidence of adverse events,clinical indicators,and TFC values were compared between the two groups.Results The clinical efficacy of the observation group(94.87%)was higher than that of the control group(76.92%)(P<0.05);the adverse event rate of the observation group(7.69%)was lower than that of the control group(25.64%),and the difference was statistically significant(P<0.05);LVEF and NO in the observation group were higher than those in the control group,and BNP,NE,and CRP were lower than those in the control group.The differences were all statistically significant(P<0.05);The TFC values of the right coronary artery,left circumflex artery,and left anterior descending branch of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Choosing fasudil to treat low-risk patients with acute coronary syndrome can improve their cardiac function and vascular endothelial function,and reduce the incidence of adverse events.