动态24h食管pH监测对胃食管反流患者生活质量的影响

Effect of Dynamic 24-hour Esophageal pH Monitoring on Quality of Life in Patients with Gastroesophageal Reflux

目的探讨动态24 h食管pH监测对胃食管反流(gastroesophageal reflux disease,GERD)患者生活质量(the quality of live,QOL)的影响。方法2021年6月至2022年3月于锦州医科大学附属第一医院行动态24 h食管pH监测的211名患者纳入研究,分析其生活质量及动态24 h食管pH监测各参数等指标。采用Spearman相关分析探讨动态24 h食管pH监测各参数与生活质量之间的相关性,利用t检验分析动态24 h食管pH监测中不同组别其立位各参数与卧位各参数间的大小对生活质量的影响。结果动态24 h食管pH监测中各参数与生活质量之间均存在负向相关关系,差异有统计学意义(P<0.05);将动态24 h食管pH监测中立位各参数与卧位各参数进行分组比较后分析发现,立位各参数大于卧位时,其生活质量更高,在酸反流时间、酸反流时间百分比、长反流时间组别中立位大于卧位时,差异有统计学意义(P<0.05)。结论动态24 h食管pH监测中其立位和(或)卧位和(或)餐后酸反流时间、酸反流次数、酸反流时间百分比、长反流数量、长反流时间的参数数值越大,生活质量越低;立位酸反流时间、立位酸反流时间百分比、立位长反流时间大于卧位时,其生活质量相对更高,可以通过增加立位时间、减少卧位时间、减少餐后反流的发生来提高GERD患者的生活质量。

Objective To investigate the effect of dynamic 24-hour esophageal pH monitoring on the quality of life(QOL)of patients with gastroesophageal reflux disease(GERD).Methods 211 patients who underwent dynamic 24-hour esophageal pH monitoring in the First Affiliated Hospital of Jinzhou Medical University from June 2021 to March 2022 were enrolled in the study,and their quality of life and parameters of dynamic 24-hour esophageal pH monitoring were analyzed.Spearman correlation analysis was used to explore the correlation between dynamic 24-hour esophageal pH monitoring parameters and quality of life,and t test was used to analyze the impact of different groups of parameters in vertical position and decubial position on quality of life in dynamic 24-hour esophageal pH monitoring.Results There was a negative correlation between the parameters of 24-hour esophageal pH monitoring and quality of life,and the difference was statistically significant(P<0.05);after group comparison of parameters of 24-hour dynamic esophageal pH monitoring in neutral position and in decubitus position,it was found that when the parameters of upright position were larger than those of decubitus position,the quality of life was higher.There were statistically significant differences in acid reflux time,percentage of acid reflux time and long reflux time group when neutral position was larger than decubitus position(P<0.05).Conclusion In dynamic 24-hour esophageal pH monitoring,the higher the parameters of acid reflux time,acid reflux times,percentage of acid reflux time,long reflux number and long reflux time in the upright and/or decubitus postures and/or in the postprandial period were,the lower the quality of life was.When the time of acid reflux,percentage of acid reflux time and long reflux time in orthostatic position were longer than those in decubitus position,the quality of life of patients with GERD was relatively higher.The quality of life of patients with GERD could be improved by increasing the time of orthostatic position,reducing the time of decubitus position,and reducing the occurrence of postprandial reflux.