柴芩清宁胶囊联合奥司他韦颗粒对乙型流感患者的疗效研究

Study on the Effect of Chaiqin Qingning Capsule Combineds with Oseltamivir Granules in the Treatment of Influenza B Virus Infected Patients

目的:探讨柴芩清宁胶囊与奥司他韦颗粒联合应用于乙型流感病毒感染所致急性上呼吸道感染的效果。方法:选取北京航天总医院2021年1月至2022年1月期间收治的90例急性上呼吸道感染患者。以随机数表法分观察组和对照组,各45例。分别给予柴芩清宁胶囊联合奥司他韦颗粒、奥司他韦颗粒治疗。比较两组疗效及症状(高热、咽痛、鼻塞、疲劳)缓解时间,记录治疗前后C反应蛋白(CRP)、降钙素原(PCT)水平及生活质量评价量表(SF-36)变化及治疗期间不良反应发生情况。结果:观察组患者治疗总有效率为97.78%,高于对照组的84.44%,差异具有统计学意义(P<0.05)。观察组患者的疲劳、高热、鼻塞、咽痛等症状缓解时间均短于对照组,差异具有统计学意义(P<0.05)。治疗后两组患者的CRP、PCT水平均较治疗前降低,且治疗后观察组的CRP、PCT水平低于对照组,差异具有统计学意义(P<0.05)。治疗后两组患者的躯体功能、物质生活、情感职能、社会功能评分均高于治疗前,且治疗后观察组的躯体功能、物质生活、情感职能、社会功能评分高于对照组,差异具有统计学意义(P<0.05)。两组患者的的不良反应发生率比较,差异无统计学意义(P>0.05)。结论:柴芩清宁胶囊与奥司他韦颗粒治疗乙型流感病毒感染所致的急性上呼吸道感染效果更优,可快速缓解症状,抑制炎症因子表达,提高患者生活质量,且不良反应少。

Objective To investigate the effect of Chaiqin Qingning capsules combined with oseltamivir granules on acute upper respiratory tract infection caused by influenza B virus infection.Methods A total of 90 patients with acute upper respiratory tract infection admitted to Beijing Aerospace General Hospital from January 2021 to January 2022 were selected.Randomly divided into an observation group and a control group,with 45 cases in each group.Chaiqin Qingning capsules combined with oseltamivir granules and oseltamivir granules were given for the two groups respectively.The curative effect and relief time of symptoms(high fever,sore throat,stuffy nose and fatigue)were compared between the two groups,and changes of C-reactive protein(CRP),procalcitonin(PCT)and quality of life assessment scale(SF-36)before and after treatment were recorded,as well as the incidence of adverse reactions during treatment.Results The total effective rate of the observation group was 97.78%,higher than 84.44%of the control group,the difference was statistically significant(P<0.05).The relief time of fatigue,high fever,nasal congestion,sore throat and other symptoms in the observation group were shorter than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of CRP and PCT in the two groups were lower than those before treatment,and the levels of CRP and PCT in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the scores of physical function,material life,emotional function and social function in the two groups were higher than those before treatment,and the scores of the physical function,material life,emotional function and social function in the observation group were higher than those in the control group,with statistical significances(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Chaiqin Qingning capsules combined with oseltamivir granules are more effective in the treatment of acute upper respiratory tract infection caused by influenza B virus infection,and they can quickly relieve symptoms,inhibit the expression of inflammatory factors and improve the quality of life of patients,and less adverse reactions safe and effective.