疏肝泻热合剂治疗胃食管反流病患者的临床效果研究

Clinical Effect Study of Shugan Xiere Mixture in the Treatment of Patients with Gastroesophageal Reflux Disease

目的:探究疏肝泄热合剂联合常规西药在胃食管反流病(GERD)治疗中的应用价值。方法:选择2021年1月至2022年1月于泉州市中医院脾胃科接受治疗的84例GERD患者为研究对象,以随机数字表法分为观察组与对照组,每组42例。对照组患者给予常规西药治疗,观察组患者给予疏肝泄热合剂联合常规西药治疗,两组患者均持续用药1个月。治疗结束后评价两组患者的临床效果,比较两组患者治疗前后中医证候评分、生活质量[GERD生活质量量表(GERD-HRQL)]及不良反应发生情况。结果:观察组患者的治疗总有效率为97.62%(41/42),高于对照组的83.05%(34/42),差异具有统计学意义(P<0.05)。两组患者治疗后中医各证候评分较治疗前降低,且观察组患者治疗后中医各证候评分低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后GERD-HRQL评分较治疗前降低,且观察组患者治疗后GERD-HRQL评分低于对照组,差异具有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:疏肝泄热合剂联合常规西药治疗GERD能提高治疗效果,改善胃黏膜分泌功能,促进病情改善,提高患者生活质量,且安全性较好。

Objective To explore the application value of Shugan Xiezhi mixture combined with conventional Western medicine in the treatment of gastroesophageal reflux disease(GERD).Methods 84 patients with GERD who received treatment in department of spleen and stomach of Quanzhou Hospital of Traditional Chinese Medicine from January 2021 to January 2022-January 2014 were selected as the research objects.They were divided into an observation group and a control group by random number table method,with 42 patients in each group.The control group was given conventional western medicine treatment,the observation group was given Shugan Xiere mixture combined with conventional western medicine treatment,the two groups of patients continued to take medicine for 1 month.After treatment,the clinical effects of the two groups were evaluated,and traditional Chinese medicine(TCM)syndromes score,quality of life[GERD quality of life scale(GERD-HRQL)]and adverse reactions were compared between the two groups before and after treatment.Results The total effective rate of the observation group was 97.62%(41/42),which was higher than 83.05%(34/42)of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of TCM syndromes in the two groups were lower than those before treatment.After treatment,the scores of TCM syndromes in the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).After treatment,The GERD-HRQL score of the two groups was lower than that before treatment,and the GERD-HRQL score of the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Shugan Xiere mixture combined with conventional western medicine can improve the therapeutic effect,gastric mucosa secretion function,promote the improvement of the condition,improve the quality of life of patients with GERD,and has a good safety.