贵阳市1000例患者25⁃羟维生素D缺乏及临床特征

The deficiency and clinical characteristics of 25-(OH)-VitD in 1000 orthopedic patients in Guiyang

目的研究某医院骨科保守治疗患者25-(OH)-VitD水平及临床特征。方法回顾性分析2016年1月-2021年6月在贵州省骨科医院接受保守治疗患者的血清25-(OH)-VitD的结果,分析25-(OH)-VitD与正常值下限之间的差异情况,分析该类患者25-(OH)-VitD的分布特点与临床特征。结果本地区研究对象25-(OH)-VitD均值为(18.354±6.294)ng/mL,与正常下限30 ng/mL的差值为-11.646(95%CI:-12.037~11.255)。单样本t检验结果提示,研究对象的25-(OH)-VitD均值与25-(OH)-VitD理想下限的差异有统计学意义(t=-58.507,P=0.000)。不同性别25-(OH)-VitD水平存在显著性差异(P=0.000<0.01)。体质量指数与25-(OH)-VitD存在正相关。女性、低体质量指数、高龄是25-(OH)-VitD缺乏的危险因素。研究人群的碱性磷酸酶与25-(OH)-VitD水平存在负相关。结论贵阳地区经骨科保守治疗颈肩腰腿痛住院的患者25-(OH)-VitD存在普遍性不足。女性、低体质量指数、高龄是25-(OH)-VitD缺乏的危险因素。研究对象的碱性磷酸酶与25-(OH)-VitD水平存在负相关。

Objective To determine the level and clinical characteristics of 25 hydroxyvitamin D in the conservative treatment ward of a Orthopedic hospital in Guiyang.Methods The result of serum 25 hydroxyvitamin D in hospitalized patients with neck,shoulder,waist and leg pain in the Department of orthopedics of Guizhou orthopedic hospital from January 2016 to June 2021 were analyzed retrospectively,and the difference between 25 hydroxyvitamin D and the lower limit of normal value was analyzed.Results The mean value of 25 hydroxyvitamin D was(18.354±6.294)ng/mL,and the difference from the lower normal limit of 30 ng/mL was-11.646(95%CI:-12.037-11.255).The result of single sample t-test showed that the difference between the mean value of 25 hydroxyvitamin D and the ideal lower limit of 25 hydroxyvitamin D was statistically significant(t=-58.507,P=0.000).There was significant difference in 25 hydroxyvitamin D between different gender(P=0.000<0.01).BMI was positively correlated with 25 hydroxyvitamin D.Women,low BMI and old age were the risk factors of 25 hydroxyvitamin D deficiency.Alkaline phosphatase was negatively correlated with the level of 25 hydroxyvitamin D.Conclusion There is a general deficiency of 25 hydroxyvitamin D in the Department of orthopedics(Department of neck,shoulder,waist and leg pain)in Guiyang.Female,low BMI and old age are the risk factors of 25 hydroxyvitamin D deficiency.Alkaline phosphatase was negatively correlated with the level of 25 hydroxyvitamin D.