SOX4在消化系统恶性肿瘤中的研究进展

Research progress of SOX4 in digestive system malignant tumors

SOX4是SOX家族C组亚科的成员,它可能通过赋予癌细胞生存、迁移和侵袭能力来促进肿瘤发生发展。目前已有多种证据支持SOX4是一种重要的癌基因的观点。SOX4在多种恶性肿瘤中过表达,包括消化系统肿瘤,而消化系统肿瘤是发展中国家癌症患者死亡的最常见原因。近年来,SOX4引起恶性转化的分子机制及其与消化系统肿瘤的关系成为研究的焦点和前沿领域。本文就SOX4在消化系统肿瘤中的研究现状进行综述。

SOX4 is a member of the group C subfamily from the SOX family,and it may promote tumorigenesis by conferring the ability of cancer cells to survive,migrate and invasive.There are multiple lines of evidence supporting the idea that SOX4 is an important oncogene.SOX4 is overexpressed in a variety of malignancies,including a variety of digestive system tumors,which are the most common cause of death among cancer patients in developing countries.In recent years,the molecular mechanism of SOX4-induced malignant transformation and its relationship with digestive system tumors have become a focus of research and a frontier area.This article reviews the research status of SOX4 in digestive system tumors.