静脉溶栓治疗老年急性脑梗死患者的安全性和有效性

Safety and effectiveness of intravenous thrombolysis in elderly patients with acute cerebral infarction

目的探讨经静脉溶栓治疗老年急性脑梗死患者的安全性和有效性。方法选取2017年5月至2020年5月本院收治的52例急性脑梗死患者作为研究对象,按照治疗方案不同分为常规组和研究组,每组26例。常规组采用药物口服方案治疗,研究组在常规组基础上联合静脉溶栓方案治疗,比较两组临床疗效(血管再通率、远端血流恢复率)、预后质量和并发症发生率。结果研究组血管再通率、远端血流恢复率均明显高于常规组,差异有统计学意义(P<0.05)。治疗后,研究组美国国立卫生研究院卒中量表(NIHSS)评分低于常规组,改良Barthel指数评估量表(MBI)评分高于常规组,差异有统计学意义(P<0.05)。研究组并发症发生率低于常规组,差异有统计学意义(P<0.05)。结论采用静脉溶栓方案治疗急性脑梗死效果显著,可有效提高患者血管再通率及远端血流再恢复率,改善其神经功能及生活能力,提高临床疗效。

Objective To explore the safety and effectiveness of intravenous thrombolysis in the treatment of elderly patients with acute cerebral infarction.Methods 52 patients with acute cerebral infarction who were admitted to our hospital from May 2017 to May 2020 were selected as the research subjects,and they were divided into the routine group and the study group according to the different treatment plans,with 26 cases in each group.The routine group was treated with oral drug regimen,and the study group was treated with intravenous thrombolysis on the basis of routine group,the clinical efficacy(vascular recanalization rate,distal blood flow recovery rate),prognosis quality and complication rate were compared between the two groups.Results The vascular recanalization rate and distal blood flow recovery rate in the study group were significantly higher than those in the routine group,and the difference was statistically significant(P<0.05).After treatment,the National Institute of Health stroke scale(NIHSS)scores of the study group was lower than that of the routine group,and the modified Barthel index(MBI)scores of the study group was higher than that of the routine group,and the difference was statistically significant(P<0.05).The incidence of complications in the study group was lower than that in the routine group,and the difference was statistically significant(P<0.05).Conclusion Intravenous thrombolysis has the significant effect in the treatment of acute cerebral infarction,which can effectively improve the vascular recanalization rate and distal blood flow recovery rate of patients,improve their neurological function and living ability,and improve clinical efficacy.