摘要
复发性流产(recurrent spontaneous abortion,RSA)是育龄期女性常见不良妊娠结局,其病因复杂,至今尚不明确。其中,母-胎界面微环境在维持妊娠方面发挥着关键作用。母-胎界面微环境主要包括滋养层细胞、蜕膜基质细胞和免疫细胞,而这些细胞数量或功能异常可能会诱发母-胎界面微环境的改变,如螺旋动脉重塑障碍、蜕膜化异常等,从而导致RSA。本文围绕这三种主要细胞在RSA发生中的作用和机制进行综述。
Recurrent spontaneous abortion(RSA)is a common adverse pregnancy outcome in women of childbearing age and its etiology is complex and still not clear.The maternal-fetal interface microenvironment plays a key role in maintaining pregnancy.There are trophoblast cells,decidual stromal cells and immune cells in the maternal-fetal interface microenvironment.The abnormal number or function of these cells may induce changes in the microenvironment of maternal-fetal interface,such as spiral artery remodeling disorder and abnormal decidualization,which may lead to RSA.This review discusses the role and mechanism of these three main cells in RSA.
作者
冯丹
石文静
严琴
孙春青
毕星宇
张秀萍
许素铭
王耀琴
武学清
Feng Dan;Shi Wenjing;Yan Qin;Sun Chunqing;Bi Xingyu;Zhang Xiuping;Xu Suming;Wang Yaoqin;Wu Xueqing(Shanxi Medical University,Taiyuan 030001,China;Center of Reproductive Medicine,Children's Hospital of Shanxi and Women Health Center of Shanxi,Taiyuan 030013,China)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2022年第5期518-523,共6页
Chinese Journal of Reproduction and Contraception
基金
国家重点研发计划(2018YFC1002103)。
关键词
复发性流产
母-胎界面
免疫细胞
滋养层细胞
蜕膜基质细胞
Recurrent spontaneous abortion
Maternal-fetal interface
Immune cells
Trophoblast cell
Decidual stromal cells
