TRPM2通道与炎症反应

TRPM2 channel and inflammation

瞬时感受器电位M2型(TRPM2)通道是一种非谷氨酸依赖性离子通道,是瞬时受体电位(TRP)通道超家族成员之一。不同致病因素作用于各种免疫细胞,引起TRPM2通道开放,导致阳离子内流,尤其是Ca^(2+),进而调节诸多信号通路,引起炎症反应的发生发展。本文聚焦TRPM2通道在炎症反应中的免疫学作用,期望为靶向TRPM2通道决策炎症相关疾病的治疗措施拓展新的思路。

Transient receptor potential M2(TRPM2)channel,a glutamate-independent ion channel,is a member of the transient receptor potential(TRP)channel superfamily.Different pathogenic factors act on all kinds of immune cells,causing the opening of TRPM2 channels,resulting in cation influx,especially Ca^(2+),which in turn regulates many signaling pathways and participates in development of inflammatory responses.The article focuses on the immunological roles of TRPM2 channels during inflammation,and provides a new way for targeting TRPM2 channels to determine therapeutic strategies for inflammation-related diseases.