肺力咳合剂联合孟鲁司特治疗老年感染后咳嗽的效果分析

Effect analysis of Feilike mixture combined with montelukast in the treatment of post-infection cough in the elderly

目的分析肺力咳合剂联合孟鲁司特治疗老年感染后咳嗽的效果。方法80例老年感染后咳嗽患者,以随机数字表法分为常规组与实验组,每组40例。常规组患者给予孟鲁司特治疗,实验组患者在常规组基础上给予肺力咳合剂治疗。比较两组治疗效果、治疗前后超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、咳嗽症状积分、咳嗽明显缓解时间、症状消失时间。结果实验组治疗总有效率为97.50%,高于常规组的75.00%,差异有统计学意义(P<0.05)。治疗后,两组hs-CRP、PCT、TNF-α、咳嗽症状积分均较治疗前降低,且实验组hs-CRP(4.14±0.21)mg/L、PCT(1.72±0.11)μg/L、TNF-α(1.24±0.21)ng/ml、咳嗽症状积分(0.34±0.15)分均低于常规组的(8.56±0.56)mg/L、(4.25±0.21)μg/L、(2.25±0.28)ng/ml、(1.15±0.13)分,差异有统计学意义(P<0.05)。实验组咳嗽明显缓解时间(2.94±1.28)d、症状消失时间(4.87±1.84)d均短于常规组的(5.04±1.97)、(6.57±2.14)d,差异有统计学意义(P<0.05)。结论孟鲁司特联合肺力咳合剂治疗老年感染后咳嗽患者效果确切,可改善相关症状和控制机体炎症,具有临床应用价值。

Objective To analyze the effect of Feilike mixture combined with montelukast in the treatment of post-infection cough in the elderly.Methods A total of 80 elderly patients with post-infection cough were randomly divided into conventional group and experimental group,with 40 cases in each group.Patients in the conventional group were treated with montelukast,and patients in the experimental group were treated with Feilike mixture on the basis of the conventional group.The therapeutic effect,high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT),tumor necrosis factor-α(TNF-α)and cough symptom scores before and after treatment,cough remission time,and symptom disappearance time were compared between the two groups.Results The total effective rate of treatment in the experimental group was 97.50%,which was higher than 75.00%in the conventional group,and the difference was statistically significant(P<0.05).After treatment,the hs-CRP,PCT,TNF-αand cough symptom score in the two groups were lower than those before treatment in this group,and the hs-CRP(4.14±0.21)mg/L,PCT(1.72±0.11)μg/L,TNF-α(1.24±0.21)ng/ml,cough symptom score(0.34±0.15)points of the experimental group were lower than(8.56±0.56)mg/L,(4.25±0.21)μg/L,(2.25±0.28)ng/ml,(1.15±0.13)points of conventional group.All the differences were statistically significant(P<0.05).The cough remission time in the experimental group was(2.94±1.28)d,and the symptom disappearance time was(4.87±1.84)d,which were shorter than(5.04±1.97)and(6.57±2.14)d in the conventional group,and the differences were statistically significant(P<0.05).Conclusion Montelukast combined with Feilike mixture is effective in treating post-infection cough in the elderly,and can improve related symptoms and control inflammation,which has the value of clinical application.