比索洛尔治疗冠心病合并快速性心律失常的效果观察

Efficacy of bisoprolol on patients with coronary heart disease complicated by tachyarrhythmia

目的探讨比索洛尔治疗冠心病合并快速性心律失常的临床疗效。方法抽取2020年1月至2022年1月郑州人民医院收治的冠心病合并快速性心律失常患者60例,采取双色球法将其分为对照组和观察组,每组30例。两组均予以扩张冠状动脉、调脂、抗血小板聚集等基础治疗,在此基础上,对照组给予美托洛尔治疗,观察组给予加比索洛尔治疗。比较两组疗效、治疗前后心功能指标和心率情况、不良反应发生情况。结果观察组总有效率(73.33%,29/30)高于对照组(73.33%,22/30),P<0.05。治疗前,两组左室射血分数、右心室舒张末内径、舒张期右心室前壁厚度和呼吸频率比较差异未见统计学意义(P>0.05);治疗后,两组患者上述各指标均较治疗前显著改善(P均<0.05),但两组间比较差异未见统计学意义(P>0.05)。治疗前,两组心率比较差异未见统计学意义(P>0.05);治疗后,观察组心率[(68.41±3.62)次/min]低于对照组[(75.45±4.55)次/min],P<0.05。两组各药物不良反应发生率比较差异未见统计学意义(P>0.05)。结论冠心病患者于常规基础治疗上予以比索洛尔治疗,可提高临床疗效,改善患者心率指标,且安全性好。

Objective To investigate the therapeutic effect of bisoprolol on patients with coronary heart disease(CHD)complicated by tachyarrhythmia.Methods A total of 60 patients with CHD combined with tachyarrhythmia admitted to Zhengzhou People’s Hospital from January 2020 to January 2022 were selected,and they were divided into control group and observation group by the double-color ball method,with 30 cases in each group.The two groups were given basic therapy such as coronary artery expansion,lipid regulation and anti-platelet aggregation,while the control group was treated with metoprolol,and the observation group was treated with bisoprolol.The curative effects,preoperative and postoperative cardiac function indexes,heart rate and adverse reactions of the two groups were compared.Results The total effective rate of the observation group(73.33%,29/30)was higher than that of the control group(73.33%,22/30),P<0.05.Before treatment,there was no significant difference in cardiac function indexes such as left ventricular ejection fraction,right ventricular end-diastolic inner diameter,right ventricular anterior wall thickness and respiratory rate between the two groups(P>0.05);after treatment,the above indexes of the two groups were significantly improved,compared with those before treatment(P<0.05);but there was no significant difference in these indexes between the two groups after treatment(P>0.05).Before treatment,there was no significant difference in heart rate between the two groups(P>0.05);after treatment,the heart rate of the observation group was(68.41±3.62)times/min,lower than(75.45±4.55)times/min of the control group(P<0.05).There was no significant difference in adverse reaction between the two groups(P>0.05).Conclusions Bisoprolol based on the routine treatment of CHD can improve the clinical efficacy and the heart rate index of patients,with good safety.