艾瑞昔布超前镇痛联合地佐辛对下颌骨骨折患者术后的镇痛疗效

Analgesic Effect of Erecoxib Preemptive Analgesia Combined with Dezocine on Postoperative Analgesia in Patients with Mandibular Fractures

观察分析艾瑞昔布超前镇痛联合地佐辛对下颌骨骨折手术患者的术后镇痛效果.方法:选择大连市中心医院颌面外科2018年1月-2019年12月入院行下颌骨骨折手术患者60例,用随机数字表法随机分为3组,空白对照组(A组)、艾瑞昔布组(B组)、艾瑞昔布联合地佐辛组(C组),每组20例.术前晚,A组患者不给予任何止痛药物;B组患者给予艾瑞昔布1片超前镇痛;C组患者给予艾瑞昔布1片超前镇痛,术后即刻给予地佐辛1支肌注镇痛.观察3组患者术后6小时、12小时、24小时疼痛的VAS评分,对术后镇痛效果进行对比.结果:术后6小时比较,B,C组VAS评分低于A组,且C组VAS评分低于B组,差异有统计学意义(P<0.05);术后12小时比较,B,C组VAS评分低于A组,差异有统计学意义(P<0.05),但B组与C组VAS评分,差异无统计学意义(P>0.05);术后24小时比较,3组VAS评分差异无统计学意义(P>0.05).结论:对下颌骨骨折手术患者,应用艾瑞昔布超前镇痛可减轻下颌骨骨折患者术后疼痛,但艾瑞昔布联合地佐辛术后镇痛效果最佳.

To observe and analyze the postoperative analgesia effect of erecoxib preemptive analgesia combined with dezocine on patients with mandibular fractures.Methods:A total of 60 patients who underwent man-dibular fracture surgery from January 2018 to December2019 in the Department of Maxillofacial Surgery,Dalian Cen-tral Hospital were selected and randomly divided into 3 groups by random number table method,blank control group(group A),Erecoxib Cloth group(group B),erecoxib combined with dezocine group(group C),20 cases in each group.The night before surgery,patients in group A were not given any analgesics;patients in group B were given 1 tablet of erecoxib for preemptive analgesia;patients in group C were given 1 tablet of erecoxib for preemptive analge-sia,and 1 tablet of dezocine immediately after surgery Intramuscular analgesia.The VAS scores of the three groups of patients at 6h,12h,and 24h after the operation were observed,and the postoperative analgesic effects were com-pared.Results:Compared at 6 hours after operation,the VAS score of group B and C was lower than that of group A,and the VAS score of group C was lower than that of group B,and the difference was statistically significant(P<0.05);compared at 12 hours after operation,the VAS score of group B and C was lower In group A,the difference was statistically significant(P<0.05),but there was no significant difference in VAS score between group B and group C(P>0.05).There was no significant difference in VAS score between the three groups at 24 hours after op-eration(P>0.05).(P>0.05).Conclusion:For patients undergoing mandibular fracture surgery,preemptive anal-gesia with erecoxib can reduce postoperative pain in patients with mandibular fractures,but erecoxib combined with dezocine has the best postoperative analgesia effect.