ceRNA调控网络在骨关节炎中的研究进展及中医药干预现状

Research progress of ceRNA regulatory network in osteoarthritis and current status of Chinese medicine intervention

骨关节炎(osteoarthritis,OA)是骨关节疾病中最常见的疾病之一,其病因复杂多样,发病机制尚不清楚,制约有效诊治。详细总结各种非编码RNA和假基因的生物学功能和特点,阐述它们作为竞争内源性RNA(competing endogenous RNA,ceRNA)在调控软骨细胞增殖与凋亡、细胞自噬、细胞外基质代谢、炎症反应、免疫失调、氧化应激损伤等OA生物学过程中至关重要的作用,并重点介绍经过验证的ceRNA参与OA的生物学功能。此外,讨论当前ceRNA理论的局限性,提出可能的方向,展望ceRNA作为新的治疗靶点、预后转归和诊断标志物的作用,并介绍中医药通过ceRNA机制治疗OA的现状。

Osteoarthritis(OA)is one of the most common bone and joint diseases,and its etiology is complex and diverse,and the pathogenesis is still unclear,which restricts effective diagnosis and treatment.The biological functions and characteristics of various non-coding RNA and pseudogenes are summarized in detail,and their critical roles as competing endogenous RNA(ceRNA)in regulating OA biological processes such as chondrocyte proliferation and apoptosis,cellular autophagy,extracellular matrix metabolism,inflammatory response,immune dysregulation,and oxidative stress damage are described,and highlight the involvement of validated ceRNA in the biological functions of OA.In addition,the limitations of current ceRNA theories are discussed,possible directions are proposed,the role of ceRNA as new therapeutic targets,prognostic regression and diagnostic markers is envisioned,and the current status of Chinese medicine in treating OA through ceRNA mechanisms is presented.