摘要
上转换纳米粒子具有独特的反斯托克斯发光特性,可以将长波长的光转化为短波长的光。由于其出色的光物理特性,如较大的斯托克斯位移、较低的自发荧光背景、长时间稳定的发光、抗光漂白以及较高的生物穿透深度等,上转换纳米材料被广泛应用于生物成像、药物治疗、生物检测等领域。本文首先介绍了上转换纳米材料的发光机制和合成方法,然后总结了上转换纳米材料在生物成像、药物治疗、生物检测领域的最新应用,并介绍了课题组近年来在这些领域取得的进展。最后,展望了上转换纳米材料在生物医学领域的应用和发展趋势。
Upconversion nanoparticles show a unique anti-Stokes luminescent property,which can convert long wavelength light into short wavelength light.Due to its excellent photophysical properties,such as large anti-Stokes shift,low autofluorescence background,long-term luminescence stability,anti-photobleaching and high biological penetration depth,upconversion nanoparticles are widely used in biological imaging,drug therapy,bi⁃ological detection and other fields.In this review,we first introduce the luminescent mechanism and preparation methods of upconversion nanoparticles,and then conclude the recent applications of upconversion nanoparticles in biological imaging,drug therapy,biological detection,anti-counterfeiting,display,solar cells and other fields.It also introduces the progress of our group in these fields in recent years.Finally,the application and de⁃velopment trend of upconversion nanoparticles in biomedical field are prospected.
作者
陈振江
赵谊华
胡睿
林桂淼
屈军乐
刘丽炜
Chen Zhenjiang;Zhao Yihua;Hu Rui;Lin Guimiao;Qu Junle;Liu Liwei(Key Laboratory of Optoelectronics Devices and Systems of Ministry of Education/Guangdong Province,College of Opto-electronics Engineering,Shenzhen University,Shenzhen 518060,China;College of Public Health,Department of Medicine,Shenzhen University,Shenzhen 518073,China)
出处
《中国稀土学报》
EI
CAS
CSCD
北大核心
2022年第4期533-549,共17页
Journal of the Chinese Society of Rare Earths
基金
国家自然科学基金项目(61961136005,61935012,61620106016,61835009)
深圳市重点项目(JCYJ20200109105404067)
深圳市基础研究项目(JCYJ2018030512490216,JCYJ20190808153803952)资助。
关键词
上转换发光
纳米材料
生物成像
药物治疗
生物检测
稀土
upconversion luminescence
nanoparticles
bioimaging
drug therapy
bio-detection
rare earths