上转换纳米材料:机制、合成和生物应用

Upconversion Nanoparticles:Mechanisms,Synthesis and Biology Applications

上转换纳米粒子具有独特的反斯托克斯发光特性,可以将长波长的光转化为短波长的光。由于其出色的光物理特性,如较大的斯托克斯位移、较低的自发荧光背景、长时间稳定的发光、抗光漂白以及较高的生物穿透深度等,上转换纳米材料被广泛应用于生物成像、药物治疗、生物检测等领域。本文首先介绍了上转换纳米材料的发光机制和合成方法,然后总结了上转换纳米材料在生物成像、药物治疗、生物检测领域的最新应用,并介绍了课题组近年来在这些领域取得的进展。最后,展望了上转换纳米材料在生物医学领域的应用和发展趋势。

Upconversion nanoparticles show a unique anti-Stokes luminescent property,which can convert long wavelength light into short wavelength light.Due to its excellent photophysical properties,such as large anti-Stokes shift,low autofluorescence background,long-term luminescence stability,anti-photobleaching and high biological penetration depth,upconversion nanoparticles are widely used in biological imaging,drug therapy,bi⁃ological detection and other fields.In this review,we first introduce the luminescent mechanism and preparation methods of upconversion nanoparticles,and then conclude the recent applications of upconversion nanoparticles in biological imaging,drug therapy,biological detection,anti-counterfeiting,display,solar cells and other fields.It also introduces the progress of our group in these fields in recent years.Finally,the application and de⁃velopment trend of upconversion nanoparticles in biomedical field are prospected.