载药微球的理化特性及其在肝癌介入治疗中的应用进展

Physical and chemical properties of drug-eluting beads and its application progress in interventional therapy of hepatocellular carcinoma

载药微球化疗栓塞术(DEB-TACE)是不可切除肝癌的一种介入治疗技术,具有栓塞肿瘤血管和缓释化疗药物的双重特性.目前用于临床的载药微球主要有DC/LC Beads微球、HepaSphere微球、CalliSpheres微球以及Tandem微球,它们的理化特性各有不同.本文就上述载药微球的理化特性、临床应用、并发症和相关不足作一综述.

Drug-eluting beads transhepatic arterial chemoembolization(DEB-TACE)is an emerging interventional treatment technique for unresectable hepatocellular carcinoma(HCC),which carries dual characteristics of obstructing tumor blood vessels and slowly releasing chemotherapy drugs.At present,the drug-eluting beads used in clinical practice mainly include DC/LC beads,HepaSpherebeads,CalliSpheres microspheres and Tandem beads,and each of them has its own physical and chemical characteristics.This paper aims to make a comprehensive review about each of above mentioned drug-eluting beads,focusing on their physical and chemical properties,clinical applications,common complications and related deficiencies.