摘要
目的探讨武汉市部分育龄期男性血清多氯联苯(polychlorinated biphenyls,PCBs)水平及其影响因素。方法依托于2013年在武汉市开展的环境污染物暴露与男性生殖健康损害关联的横断面研究,利用同位素稀释-高分辨气相色谱-高分辨质谱法测定101名育龄期男性血清样本中12种二口恶英样多氯联苯(dioxins-like PCBs,dl-PCBs)和6种非二口恶英样多氯联苯(non-dioxin-like PCBs,ndl-PCBs)含量,采用多元线性回归模型分析育龄期男性血清dl-PCBs和ndl-PCBs水平的影响因素。结果育龄期男性血清Σdl-PCBs的浓度范围为177.85~7271.48 pg/g脂肪,中位数为1530.71 pg/g脂肪,其中CB-118占比最高;Σndl-PCBs的浓度范围为1463.23~40561.47 pg/g脂肪,中位数为5498.37 pg/g脂肪,其中CB-153占比最高。按毒性当量(toxic equivalent,TEQ)计,ΣTEQ_(dl-PCBs)含量范围为0.02~162.29 pg TEQ/g脂肪,中位数为1.77 pg TEQ/g脂肪。多元线性回归分析结果显示,育龄期男性年龄与Σ单邻位(mono-ortho)PCBs、ΣTEQ_(mono-ortho PCBs)和Σndl-PCBs呈正相关(β=0.01,95%CI 0.00~0.02;β=0.01,95%CI 0.00~0.02;β=0.02,95%CI 0.00~0.03),饮酒男性血清ΣTEQ_(dl-PCBs)水平高于不饮酒者(β=0.56,95%CI 0.13~1.00),居住地在城镇的男性血清Σndl-PCBs水平高于居住在农村者(β=0.15,95%CI 0.04~0.26)。结论武汉市部分育龄期男性存在PCBs暴露。年龄、饮酒和居住地可能会影响男性血清PCBs水平。
OBJECTIVE To measure polychlorinated biphenyls(PCBs)concentrations in serum of some reproductive aged men in Wuhan and explore the influencing factors of PCBs exposure.METHODS Based on a cross-sectional study in 2013 on the association between exposure to environmental pollutants and adverse male reproductive health,which was conducted in Wuhan.Levels of dioxins-like PCBs(dl-PCBs)and non-dioxin-like PCBs(ndl-PCBs)in 101 serum samples of men with childbearing age were analyzed via high-resolution gas chromatograph tandem high-resolution mass spectrometer(HRGC-HRMS)method.Multiple linear regression models were used to analyze the associations between PCBs levels and influencing factors.RESULTS Total concentrations of twelve dl-PCBs(Σdl-PCBs)were in range of 177.85-7271.48 pg/g lipid,the median value was 1530.71 pg/g lipid,and CB-118 was the predominant congener.For six ndl-PCBs,total concentrations(Σndl-PCBs)were in range of 1463.23-40561.47 pg/g lipid,the median value was 5498.37 pg/g lipid,and CB-153 was the predominant congener.The World Health Organization toxicity equivalent(WHO_(2005)-TEQ)of dl-PCBs(ΣTEQ_(dl-PCBs))were 0.02-162.29 pg TEQ/g lipid,the median value was 1.77 pg TEQ/g lipid.The age was positively correlated withΣmono-ortho PCBs(β=0.01,95%CI 0.00-0.02),ΣTEQ_(mono-ortho PCBs)(β=0.01,95%CI 0.00-0.02)and Σndl-PCBs(β=0.02,95%CI 0.00-0.03).Men who drank alcohol tend to show higher exposure to ΣTEQ_(dl-PCBs)(β=0.56,95%CI 0.13-1.00)than those did not drink alcohol.And higher levels of Σndl-PCBs(β=0.15,95%CI 0.04-0.26)was found in the men who reside in urban areas as compared to rural one.CONCLUSION There were PCBs exposure in some reproductive aged men in Wuhan.Age,drink alcohol status,and residence were influencing factors on PCBs.
作者
刘小方
周妍
刘潇
闻胜
曹文成
Liu Xiaofang;Zhou Yan;Liu Xiao;Wen Sheng;Cao Wencheng(Hubei Provincial Key Laboratory for Applied Toxicology,Hubei Provincial Center for Disease Control and Prevention,Wuhan 430079,China)
出处
《卫生研究》
CAS
CSCD
北大核心
2022年第4期610-616,共7页
Journal of Hygiene Research
基金
国家自然科学基金(No.81703194)
国家重点研发计划(No.2017YFC1600500)
湖北省卫生健康委青年人才项目(No.WJ2021Q049)。
关键词
多氯联苯
血清
育龄期
影响因素
polychlorinated biphenyls
serum
reproductive age
influencing factors