基于牛津郡社区卒中项目分型研究中风(中经络)急性期中医证型与检验指标相关性

Association Between TCM Syndrome Types and Test Indices in Patients in the Acute Stage of Stroke(Apoplexy Involving the Meridians):A Study Based on Oxfordshire Community Stroke Project Classification

目的基于牛津郡社区卒中项目(Oxfordshire Community Stroke Project,OCSP)分型研究中风(中经络)急性期中医证型与检验指标的相关性。方法收集225例中风(中经络)急性期患者,根据英国OCSP分型,中医辨证分型分为风痰阻络证、气虚血瘀证、风火上扰证、阴虚风动证。收集患者的既往史、生活习惯、检验指标资料,探讨中风(中经络)患者中医证型分布及OCSP分型与中医证型的关系、不同中医证型患者检测指标的变化。结果中风(中经络)患者中医证型以风痰阻络证为主。不同性别患者中医证型分布差异无统计学意义(P>0.05)。不同OCSP分型患者4种中医证型分布存在差异(P<0.05)。不同证型患者血清肌酐水平比较,差异有统计学意义(P<0.05),不同证型患者尿酸、同型半胱氨酸、三酰甘油、低密度脂蛋白胆固醇、载脂蛋白A1水平比较,差异无统计学意义(P>0.05)。结论基于OCSP分型,中风(中经络)急性期中医证型与血清肌酐具有一定的相关性。

Objective To investigate the association between TCM syndrome types and test indices in patients in the acute stage of stroke(apoplexy involving the meridians)based on Oxfordshire Community Stroke Project(OCSP)classification.Methods A total of 225patients in the acute stage of stroke(apoplexy involving the meridians)were selected and classified into different types according to OCSP classification in Britain,and based on TCM syndrome differentiation,the patients were divided into those with syndrome of wind-phlegm blocking collaterals,Qi deficiency and blood stasis syndrome,syndrome of upward disturbance of wind-fire,and syndrome of Yin deficiency with wind stirring.The data on past history,living habits,and test indices were collected to investigate the distribution of TCM syndrome types in patients with stroke(apoplexy involving the meridians),the association between OCSP classification and TCM syndrome type,and the changes in test indices in patients with different TCM syndrome types.Results The syndrome of wind-phlegm blocking collaterals was the main TCM syndrome type in the patients with stroke(apoplexy involving the meridians).There was no significant difference in the distribution of TCM syndrome types between the male and female patients(P>0.05),and there was a significant difference in the distribution of the above four TCM syndrome types between the patients with different OCSP types(P<0.05).There was a significant difference in the level of serum creatinine between the patients with different TCM syndrome types(P<0.05),while there were no significant differences in uric acid,homocysteine,triglyceride,low-density lipoprotein cholesterol,and apolipoprotein A1between these patients(P>0.05).Conclusion There is a certain association between TCM syndrome type and serum creatinine in patients in the acute stage of stroke(apoplexy involving the meridians)based on OCSP classification.