中国13省(市、自治区)妊娠糖尿病人群生殖道感染B族链球菌的Meta分析

Reproductive tract infection of Streptococcus group B in women with gestational diabetes mellitus in China: a Meta analysis

目的 系统评价中国13省(市、自治区)妊娠糖尿病人群生殖道B族链球菌感染率。方法 利用PubMed、Web of Science、EMbase、The Cochrane Library、中国期刊全文数据库(CNKI)、万方数据知识服务平台、中国生物医学文献服务系统(SinoMed)等数据库,检索中国妊娠糖尿病人群B族链球菌(Streptococcus group B,GBS)感染率的相关文献,检索时间从建立数据库至2022年3月16日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用R4.1.1软件进行Meta分析。结果 共纳入文献28篇,包括12 666例妊娠糖尿病孕妇。Meta分析显示,在妊娠期糖尿病人群中,GBS感染率约为16%(95%CI:11%~21%)。结论 中国妊娠糖尿病人群B族链球菌感染率比非GDM人群高,可增加不良妊娠结局的发生风险,应给予高度关注。

Objective To systematically review Streptococcus group B(GBS) infection in reproductive tract of women with gestational diabetes mellitus(GDM) in China. Methods Literatures were searched electronically on databases as PubMed, Web of Science, EMbase, The Cochrane Library, Chinese Journal Full Text Database(CNKI), Wanfang Data knowledge service platform, and China biomedical literature service system(SinoMed), which were up to March 16, 2022.Two researchers independently screened the literatures, extracted data and evaluated the risk of bias for the included studies.Meta-analysis was performed using R4.1.1 software. Results A total of 28 studies were included in the analysis, and 12 666 pregnant women with GDM were involved.Meta analysis showed that the prevalence of SGB infection was about 16% in women with GDM in China(95%CI:11%-21%). Conclusions The infection rate of GBS is higher in women with GDM than that in healthy pregnant women, which increases the risk of adverse pregnancy outcomes.