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代谢组学在筛选奶牛酮病生物标志物中的应用 被引量:2

Application of Metabonomics in Screening Biomarkers of Ketosis in Dairy Cows
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摘要 酮病作为围产期奶牛最为常见的一种营养代谢病,严重损害奶牛健康、生产性能、繁殖性能,其病因学的一些问题至今尚未解决。代谢组学作为系统生物学的重要组成部分,不仅可以对某一生物或细胞在某一特定生理时期内小分子量的代谢产物进行定性、定量分析,还可以为动物营养代谢疾病研究提供一定的理论基础和技术平台。本文就代谢组学在奶牛酮病生物标志物筛选上的应用进行综述。 As one of the most common nutritional and metabolic diseases in perinatal dairy cows,ketosis seriously damages the health,performance and reproductive performance of dairy cows.Some problems about its etiology have not been solved yet.Metabolomics is an important part of system biology,which can not only conduct qualitative and quantitative analysis of the small molecular weight metabolites of a certain organism or cell in a specific physiological period,but also provide a certain theoretical basis and technical platform for the study of nutritional and metabolic diseases in animals.This review summarized the application of metabolomics in marker screening of ketosis in dairy cows.
作者 安彦昊 马学虎 孙奕烁 马燕芬 AN Yanhao;MA Xuehu;SUN Yishuo;MA Yanfen(Key Laboratory of Ruminant Molecular Cell Breeding in Ningxia,School of Agriculture,Ningxia University,Yinchuan 750021,China;Institute of Animal Nutrition and Feed,Inner Mongolia Academy of Agriculture and Animal Husbandry Sciences,Huhhot 010031,China)
出处 《动物营养学报》 CAS CSCD 北大核心 2022年第8期4829-4835,共7页 CHINESE JOURNAL OF ANIMAL NUTRITION
基金 宁夏大学科研启动项目(030900002154) 内蒙古自治区科技计划项目(2021GG0025) 内蒙古农牧业创新基金项目(2019CXJJM06) 宁夏回族自治区乡村振兴科技成果引进示范推广项目(2021CGSF0206)。
关键词 生物标志物 代谢组学 奶牛 酮病 biomarkers metabonomics dairy cows ketosis
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