冠状动脉慢血流现象治疗的研究进展

Progress in the treatment of coronary slow flow phenomenon

临床上在为反复胸痛患者行冠脉造影检查时会发现部分患者冠状动脉并没有明确的狭窄,但其远端血流却灌注延迟,当除外溶栓术后、冠脉成形术后、冠脉痉挛、冠脉瘤样扩张、心肌病、瓣膜病等一系列疾病,这一现象被称为冠状动脉慢血流现象。冠状动脉慢血流现象表现为反复发作静息型心绞痛,而且可能会导致急性心肌梗死、致命性的心律失常和心源性猝死等严重的心血管事件,并降低患者的生活质量。近年来由于冠脉介入技术的不断发展,冠状动脉慢血流现象逐渐被引起重视,但人们仍然对其发病机制及治疗了解甚少,对冠状动脉慢血流现象的治疗及预后缺乏明确的认识。本文重点讨论了冠状动脉正常或接近正常的冠状动脉慢血流现象,并总结了其可能的发病机制、治疗以及该疾病的预后影响,并对冠状动脉慢血流现象的研究进展及治疗进行简单的综述。

Clinical for repeated chest pain coronary angiography found in some patients with coronary artery and no clear stenosis,but its distal blood flow is delayed perfusion,except after thrombolysis,coronary plasty,coronary spasm,coronary expansion,cardiomyopathy,valve disease and a series of diseases,this phenomenon will be called coronary artery slow flow phenomenon.Coronary slow blood flow shows recurrent resting angina and may lead to serious cardiovascular events such as acute myocardial infarction,fatal arrhythmia and sudden cardiac death,and reduce the quality of life and life of patients.In recent years,due to the continuous development of coronary intervention technology,the phenomenon of coronary slow flow has gradually been paid attention to,but people still have little understanding of its pathogenesis and treatment,and a clear understanding of the treatment and prognosis of coronary slow flow phenomenon is lacking.This paper focuses on slow flow phenomenon of normal or near normal coronary artery,and summarize the possible pathogenesis,treatment,and the prognostic impact of the disease,and make a brief review of the research progress and treatment of slow blood flow phenomena in coronary arteries.