硫酸镁对围生儿神经系统保护机制及其应用的研究进展

Research progress of protective mechanism and application of Magnesium Sulfate on perinatal nervous system

近年来新生儿脑损伤的发生率居高不下,各大研究机构均在积极探讨神经系统保护剂。硫酸镁作为非酶类抗氧化剂,在产前被证实具有预防脑瘫的作用,并且产科已经将硫酸镁纳入早产儿神经保护指南。硫酸镁具有抗炎、抗氧化、抑制细胞凋亡等保护作用,最近硫酸镁在神经系统的保护作用被国内外广泛关注,成为硫酸镁作用研究的一个热点。但硫酸镁在产后的研究相对较少,产后使用硫酸镁是否同样具有神经系统保护作用,目前尚无统一结论。本文主要探讨硫酸镁对新生儿神经系统的保护机制,针对围生期新生儿就硫酸镁的作用机制,产前、产后硫酸镁的研究,以及硫酸镁的使用剂量进行综述,旨在为临床及科研人员在硫酸镁围生期新生儿的神经系统保护的研究中提供参考。

In recent years,the incidence of neonatal brain injury remains high,and major research institutions are actively exploring neuroprotective agents.Magnesium Sulfate,as a non enzymatic antioxidant,has been proved to prevent cerebral palsy before delivery,and Magnesium Sulfate has been included in the neuroprotective guidelines for preterm infants in obstetrics.Magnesium Sulfate has the protective effects of anti-inflammatory,antioxidant and inhibition of apoptosis.Recently,the protective effect of Magnesium Sulfate on the nervous system has been widely concerned at home and abroad,and has become a hot spot in the study of the effect of Magnesium Sulfate.However,there are relatively few studies on Magnesium Sulfate in postpartum.At present,there is no unified conclusion whether postpartum use of Magnesium Sulfate has the same protective effect on nervous system.This paper mainly discusses the protective mechanism of Magnesium Sulfate on neonatal nervous system,reviews the mechanism of action of Magnesium Sulfate,the research of prenatal and postpartum Magnesium Sulfate,and the dosage of Magnesium Sulfate for perinatal newborns,in order to provide reference for clinical and scientific researchers in the research of nervous system protection of perinatal newborns.