间苯三酚与依替米星治疗急性胃肠炎致痉挛性腹痛患者的临床效果

Clinical effect of Phloroglucinol and Etimicin in the treatment of patients with spasmodic abdominal pain caused by acute gastroenteritis

目的研究间苯三酚与依替米星治疗急性胃肠炎(AG)致痉挛性腹痛患者的临床效果。方法选取2021年10月1日至2022年3月15日于江西省九江市第一人民医院急诊科接受治疗的104例AG致痉挛性腹痛患者作为研究对象,采用随机数字表法将其分为对照组(n=52)和观察组(n=52)。对照组注射盐酸消旋山莨菪碱与盐酸左氧氟沙星氯化钠,观察组注射间苯三酚与依替米星。比较两组治疗前、治疗3 d后的炎症细胞因子水平[白介素6(IL-6)、白介素8(IL-8)]。比较两组症状(包括腹泻、高体温、恶心呕吐、腹部疼痛)持续时间以及两组临床疗效。结果治疗3 d后,观察组的IL-6、IL-8水平均低于对照组,差异有统计学意义(P<0.05)。观察组腹泻、高体温、恶心呕吐、腹部疼痛持续时间均短于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组,差异有统计学意义(P<0.05)。结论间苯三酚与依替米星治疗AG致痉挛性腹痛可以有效减轻患者的炎症反应,快速缓解临床症状,临床效果颇佳。

Objective To study the clinical effect of Phloroglucinol and Etimicin in the treatment of patients with spasmodic abdominal pain caused by acute gastroenteritis(AG).Methods A total of 104 patients with spasmodic abdominal pain caused by AG treated in the Department of Emergency,the First People′s Hospital of Jiujiang City from October 1,2021 to March 15,2022 were selected as the research subjects,and they were divided into control group(n=52)and observation group(n=52)according to random number table method.The control group was injected with Racemic Anisodamine Hydrochloride and Levofloxacin Hydrochloride and Sodium Chloride,and the observation group was injected with Phloroglucinol and Etimicin.The levels of inflammatory cytokines(interleukin-6[IL-6]and interleukin-8[IL-8])between the two groups before and after 3 days of treatment were compared.The duration of symptoms(diarrhea,hyperthermia,nausea and vomiting,abdominal pain)of the two groups were compared.The clinical efficacy of the two groups was compared.Results After 3 days of treatment,the levels of IL-6 and IL-8 in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The duration of diarrhea,hyperthermia,nausea and vomiting,and abdominal pain in the observation group were shorter than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion Phloroglucinol and Etimicin in the treatment of patients with spasmodic abdominal pain caused by AG can effectively reduce the inflammatory response of patients,rapidly relieve clinical symptoms,and have good clinical effect.