抗角蛋白抗体和抗核周因子在类风湿性关节炎预测中的价值

The value of anti-keratin antibody and anti-perinuclear factor detection in the risk prediction of rheumatoid arthritis

目的分析评估AKA和APF水平在类风湿性关节炎风险预测中的价值。方法我们选择249例类风湿性关节炎患者作为研究组,选择149例体检健康的受试者作为对照组。采用Logistic回归分析受试者血液AKA以及APF与类风湿性关节炎发生风险的相关性。结果研究组患者中AKA阳性检出率(33.73%)和APF阳性检出率(43.37%)均显著高于对照组(4.03%和6.04%),差异均有统计学意义(P<0.001)。Logistic回归分析结果显示,高血压、糖尿病、AKA阳性、APF阳性均是类风湿性关节炎发生的独立危险因素(P<0.05)。结论本研究结果显示,高血压、糖尿病、AKA阳性、APF阳性均是类风湿性关节炎发生的独立危险因素。

Objective To analyze and evaluate the value of AKA and APF levels in the risk prediction of rheumatoid arthritis.Methods 249 patients with rheumatoid arthritis were selected as the research group,and 149 healthy subjects were selected as the control group.Logistic regression was used to analyze the dependency of AKA and APF with the risk of rheumatoid arthritis.Results The positive detection rates of AKA(33.73%)and APF(43.37%)in the research group were significant higher than those in the control group(4.03%and 6.04%),and the differences were statistically significant(P<0.001).Logistic regression analysis results showed that hypertension,diabetes,AKA positive,and APF positive were all independent risk factors for rheumatoid arthritis(P<0.05).Conclusion From this study,we find that hypertension,diabetes,AKA positive,APF positive are all independent risk factors for the occurrence of rheumatoid arthritis.