摘要
创伤性颅脑损伤(TBI)的发病率高、致残率高且后遗症多,其中抑郁是其最常见的精神障碍后遗症,严重影响着患者的转归及生活质量,但其发病机制目前尚不完全清楚,也无公认的预防及治疗方案。笔者回顾性总结近5年来TBI后抑郁的流行病学、危险因素、临床表现、可能机制以及治疗等方面的新发现,旨在为临床医生更有效诊治这一疾病及后续相关研究的开展提供参考。
Traumatic brain injury(TBI)is characterized by high incidence,high disability rate,and many sequelae.Depression after TBI is the most common sequelae of mental illness,which can affect the prognosis and quality of life of patients.The specific pathogenesis of post-TBI depression is not yet known,and there is no recognized prevention and treatment plan.This review aims to retrospectively summarize the epidemiology,risk factors,clinical manifestations,evaluation,possible mechanisms,and discoveries of treatment of post-TBI depression in the past 5 years,which will help clinicians manage this difficult disease more effectively and provide a reference for future research.
作者
苏秀珠
杨菲
吴黄辉
陈国忠
Su Xiuzhu;Yang Fei;Wu Huanghui;Chen Guozhong(Hospital of Joint Logistics Support Force,Fuzhou 350025,China;Institute of Brain Function and Artificial Intelligence Transformation,School of Medicine,Tongji University,Shanghai 200434,China;Department of Anesthesia and Perioperative Medicine,Shanghai Fourth People's Hospital Affiliated to Tongji University,Shanghai Key Laboratory of Anesthesia and Brain Function Regulation,Shanghai 200434,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2022年第7期721-726,共6页
Chinese Journal of Neuromedicine
基金
国家自然科学基金(81801101、81870828)
全军青年培育项目(20QNPY073)。
关键词
创伤性颅脑损伤
抑郁
治疗
Traumatic brain injury
Depression
Treatment
