细胞焦亡在脓毒症相关性脑病中的研究进展

Recent advance in role of pyroptosis in sepsis-associated encephalopathy

脓毒症相关性脑病(SAE)是脓毒症的严重并发症,其出现往往提示患者预后不良。SAE发病机制复杂,细胞焦亡参与了SAE中神经炎症、氧化应激、线粒体自噬过程。本文现围绕细胞焦亡与上述过程中关键因子P2X7受体、核转录因子-E2相关因子、腺苷酸活化蛋白激酶的关系及焦亡相关调节剂的研究进展综述如下,以期为SAE的诊疗提供参考。

Sepsis associated encephalopathy(SAE)is a serious complication of sepsis.The occurrence of SAE often indicates poor prognosis of the patients.SAE pathogenesis is complex,and pyroptosis is involved in the neuroinflammation,oxidative stress and mitochondrial autophagy in SAE.This paper reviews the relations of pyroptosis with key factors in the above process(P2X7 receptor,nuclear factor erythroid-2-related factor 2 and adenosine monophosphate-activated protein kinase)and pyroptosis related regulators to provide references for the diagnosis and treatment of SAE.