摘要
结核病(tuberculosis,TB)是由结核分枝杆菌(Mycobacterium tuberculosis,MTB)感染引起的一种严重威胁人畜健康的传染性疾病,目前仍然是全球十大致死率疾病之一[1]。据WHO报告指出:由于这两年受到COVID-19大流行的影响,TB患者的数量大幅度下降,但由于多重耐药、共患病等因素的上升以及对TB诊断、预防和服务支出的下降,导致TB的预防和治疗现状变得更加棘手[2-3]。据不完全统计,全球目前有近四分之一的MTB潜伏感染者,这部分感染者免疫力下降后,就可能发展为活动性TB患者。由此可见,结核病发生发展与机体免疫应答功能密切相关。
Tuberculosis,caused by Mycobacterium tuberculosis infection,poses a huge challenge to global health.The occurrence and development of tuberculosis depends on immune response to Mycobacterium tuberculosis in-cluding cellular immunity and humoral immunity.Cellular immunity plays an important role in the immune process of anti-Mycobacterium tuberculosis.Recent studies have identified a third subset of memory T cells,called tissue-resident memory T cells(T_(RM)).CD4^(+)T_(RM),CD8^(+)T_(RM),Treg T_(RM)and NKT T_(RM)were identified as the subsets of T_(RM).All of them permanently reside in the peripheral tissues after infection by pathogenic bacteria.CD4^(+)T_(RM)cells and CD8^(+)T_(RM)cells play critical roles in the immune response to tuberculosis.Here we review the types and functions of T_(RM)in the treatment of Mycobacterium tuberculosis infection,providing new targets and ideas for the study of tuberculosis vaccines.
作者
耿雪
宫照乾
于嘉霖
邓光存
吴晓玲
GENG Xue;GONG Zhao-qian;YU Jia-lin;DENG Guang-cun;WU Xiao-ling(Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China,School of Life Sciences,Ningxia University,Yinchuan 750021,China.)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2022年第8期1507-1513,共7页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.32060160
No.32160162)
宁夏自然科学基金重点项目(No.2022AAC02009)。
关键词
组织驻留记忆T细胞
结核分枝杆菌
疫苗
Tissue-resident memory T cells
Mycobacterium tuberculosis
Vaccine