肠道菌群在肾性贫血中作用机制的研究进展

Research advances on the mechanism of gut microbiota in renal anemia

肾性贫血是慢性肾脏病(chronic kidney disease,CKD)的常见并发症。人类肠道微生物群参与人体代谢、免疫等功能,对人类的健康调节起着至关重要的作用。研究表明肠道菌群紊乱与肾性贫血的发生、发展有着密切的关联。在CKD患者中肠道菌群紊乱可以通过促红细胞生成素生成减少、铁代谢紊乱、炎症和骨髓造血微环境紊乱等方式加重肾性贫血。而膳食纤维等益生元可以调节肠道微环境进而改善肾性贫血。本文综述了肠道菌群影响肾性贫血的作用机制及膳食纤维在其中的调节作用。

Renal anemia is a common complication of chronic kidney disease(CKD).Human gut microbiota participates in human metabolism,immunity and other functions,playing vital roles in the regulation of human health.Numerous studies have demonstrated that any disorder of gut microbiota is closely correlated with the occurrence and development of renal anemia.Gut microbiota disorder may aggravate renal anemia through lower erythropoietin production,iron metabolism disorder,aggravating inflammation and bone marrow hematopoietic microenvironment disorder.Such probiotics as dietary fiber regulates intestinal microenvironment and improves renal anemia.This review focused upon the mechanism of the effect of gut microbiota on renal anemia and its regulatory role of dietary fiber.