银杏二萜内酯葡胺联合丁苯酞治疗急性脑梗死患者临床研究

Clinical Study of Ginkgo Diterpene Lactone Meglumine Combined with Butylphthalide in the Treatment of Patients with Acute Cerebral Infarction

目的探究银杏二萜内酯葡胺联合丁苯酞治疗急性脑梗死的临床效果。方法回顾性分析我院收治的127例急性脑梗死患者的一般资料,将其依据治疗方式分为两组,对照组63例使用丁苯酞治疗,实验组64例使用银杏二萜内酯葡胺+丁苯酞治疗,比较两组治疗效果。结果治疗后两组ADL评分提高、NIHSS评分均降低,且实验组两项评分均优于对照组(P<0.05)。组内比较,两组患者治疗后IL-6、IL-8、CRP和TNF-α水平均降低(P<0.05);组间比较,实验组治疗后四项炎症因子表达水平下降幅度较对照组更高(P<0.05)。观察组临床有效率(85.94%)高于对照组(69.84%)(P<0.05)。治疗后,两组均无严重不良反应。结论银杏二萜内酯葡胺联合丁苯酞可有效改善急性脑梗死患者神经功能,有效降低炎症因子水平,临床疗效明显优于单独使用丁苯酞。

Objective To investigate the clinical efficacy of ginkgo diterpene lactone meglumine combined with butylphthalide in the treatment of patients with acute cerebral infarction.Methods The general data of 127 patients with acute cerebral infarction admitted to our hospital were retrospectively analyzed.They were divided into two groups according to the treatment methods.63 patients in the control group were treated with butylphthalide,and 64 patients in the experimental group were treated with ginkgolide glucosamine+butylphthalide.The treatment effects of the two groups were compared.Results After treatment,the ADL score of the two groups was improved,and the score of the experimental group was higher than that of the control group.The NIHSS score of the experimental group was lower than that of the control group(P<0.05).Intra-group comparison,the levels of IL-6,IL-8,CRP and TNF-αin 2 groups were decreased after treatment(P<0.05).Compared with the control group,the expression of four inflammatory factors decreased significantly in the experimental group after treatment(P<0.05).The clinical effective rate of observation group(85.94%)was higher than that of control group(69.84%)(P<0.05).After treatment,there were no serious adverse reactions in both groups.Conclusion Apricot diterpene lactone glucosamine combined with butylphthalide can effectively improve the neurological function of patients with acute cerebral infarction,effectively reduce the level of inflammatory factors,and the clinical efficacy is significantly better than butylphthalide alone.