妊娠期糖尿病患者临床特点及相关影响因素分析

Analysis of Clinical Characteristics and Related Influencing Factors in Patients with Gestational Diabetes

目的探讨妊娠期糖尿病患者临床特点及相关影响因素。方法选取妊娠期糖尿病产妇150例(观察组)、正常妊娠产妇100例(对照组)作为本次研究对象,选例时间、地点分别为2018年5月到2021年3月、商丘市第一人民医院,对研究对象其进行回顾性分析。首先比较两组产妇临床特点,其次开展单因素分析,最后以多因素Logistic回归分析法进一步进行多因素分析,针对妊娠期糖尿病发生独立危险因素进行筛选。结果观察组血清FPG、2h PG水平高于对照组(P<0.05);单因素结果分析显示,观察组孕前BMI≥25kg/m^(2)、有糖尿病家族史的产妇占比均高于对照组,血清Leptin、FPG、2h PG水平高于对照组,血清APN水平低于对照组(P<0.05);多因素Logistic回归分析结果显示,孕前BMI≥25kg/m^(2)、有糖尿病家族史、血清Leptin水平高、血清APN水平低均为妊娠期糖尿病发生的危险因素(OR=1.820,1.208,1.354,1.179,P<0.05)。结论孕前BMI≥25kg/m^(2)、有糖尿病家族史、血清Leptin水平高、血清APN水平低均为妊娠期糖尿病发生的危险因素,故而临床上应早期识别高危产妇并实施干预措施,避免产妇出现妊娠期糖尿病,改善预后。

Objective To explore the clinical characteristics and related influencing factors of patients with gestational diabetes.Methods The clinical data of 150 pregnant women with gestational diabetes were selected retrospectively as the research objects.All of them were admitted to our hospital from May 2018 to March 2021,analyze and organize its basic clinical data as the observation group,another 100 normal pregnant women who received physical examination in our hospital during the same period were selected as the control group.The clinical characteristics of the two groups of parturients were compared,the basic data were counted and single factor analysis was performed,and multivariate unconditional Logistic regression analysis was used to screen independent risk factors for the occurrence of gestational diabetes.Results Serum FPG and 2h PG levels in the observation group were higher than those in the control group(P<0.05),Single factor analysis showed that the pre-pregnancy BMI≥25kg/m^(2),the proportion of parturients with family history of diabetes in the observation group were higher than those in the control group,the serum levels of Leptin,FPG,and 2h PG were higher than those of the control group,and the serum APN levels were lower than the control group(P<0.05);The logistic regression analysis of factors showed that pre-pregnancy BMI≥25kg/m^(2),family history of diabetes,high serum Leptin levels,and low serum APN levels are all risk factors for gestational diabetes.(OR=1.820,1.208,1.354,1.179,P<0.05).Conclusion Pre-pregnancy BMI≥25kg/m^(2),family history of diabetes,high serum Leptin levels and low serum APN levels are risk factors for gestational diabetes.Therefore,corresponding prevention methods and measures can be formulated according to the relevant risk factors screened out in clinical practice.Avoid gestational diabetes in pregnant women and improve prognosis.