桥本甲状腺炎与甲状腺癌关系研究进展

Advances in the relationship between Hashimoto’s thyroiditis and thyroid cancer

桥本甲状腺炎(HT)是常见的自身免疫性疾病,其特征是免疫系统对甲状腺组织的病理性激活。甲状腺癌(TC)是内分泌系统最常见的恶性肿瘤,其中又以甲状腺乳头状癌(PTC)发病率最高。近年来HT合并TC的发病率逐渐增加,引起研究者对两者联系的多方面研究,在免疫学、内分泌以及遗传学等方面表现出的相似性,提示两者间存在一定关联。本文以肿瘤微环境为背景,从遗传学、免疫学、细胞增殖凋亡紊乱方面对两者关系的研究进展作一综述,希望通过了解它们的潜在关联,为TC提供更有效的治疗策略。

Hashimoto’s thyroiditis(HT),a common autoimmune disease,is characterized by pathological activation of the thyroid tissue by the immune system.Thyroid cancer(TC)is the most common malignant tumor of the endocrine system,among which papillary thyroid carcinoma(PTC)has the highest incident.In recent years,the incidence of HT combined with TC has gradually increased,attracting the researchers’focus.The similarities in immunology,endocrinology and genetics suggest that there is a certain correlation between them.This article will review the research progress of the relationship from genetics,immunology,cell proliferation and apoptosis disorders under the background of tumor microenvironment to understand the potential associations,providing new and more effective treatment strategies.