缬沙坦氢氯噻嗪片治疗原发性高血压合并慢性心功能不全的效果分析

Effect Analysis of Valsartan Hydrochlorothiazide Tablets in Treatment of Essential Hypertension Complicated with Chronic Cardiac Insufficiency

目的:探讨缬沙坦氢氯噻嗪片治疗原发性高血压合并慢性心功能不全的临床效果。方法:选取吉林省辽源市龙山区东吉街社区卫生服务中心2018年1月-2020年1月收治的100例原发性高血压合并慢性心功能不全患者,随机分为观察组和对照组,各50例,两组均给予吸氧、预防电解质紊乱、抗感染等治疗,对照组在此基础上口服缬沙坦治疗,观察组给予缬沙坦氢氯噻嗪片治疗,两组均连续治疗8周,比较两组患者氨基末端脑钠肽前体水平、C-反应蛋白水平及心功能指标。结果:治疗后,观察组氨基末端脑钠肽前体、C-反应蛋白水平均低于对照组,差异有统计学意义(P<0.05);治疗后观察组左室射血分数、左室舒张末期内径、左室收缩末期内径、每搏输出血量均优于对照组,差异有统计学意义(P<0.05),治疗后,观察组心率、血压水平均明显低于对照组,差异有统计学意义(P<0.05)。结论:缬沙坦氢氯噻嗪片治疗原发性高血压合并慢性心功能不全,能够迅速降低患者氨基末端脑钠肽前体和C-反应蛋白水平,改善心功能,疗效显著,值得推广。

Objective:To investigate the clinical effect of valsartan hydrochlorothiazide tablets in the treatment of essential hypertension complicated with chronic cardiac insufficiency.Methods:A total of 100 patients with essential hypertension complicated with chronic cardiac insufficiency treated in Dongji Street Community Health Service Center of Longshan District of Liaoyuan City from January 2018 to January 2020 were selected.They were randomly divided into observation group and control group,with 50 cases in each group.Both groups were given oxygen inhalation,anti-electrolyte disorder,anti-infection and other treatments.On this basis,the control group was given valsartan orally and the observation group was given valsartan hydrochlorothiazide tablets,for 8 weeks continuously.The levels of N-terminal brain natriuretic peptide precursor,C-reactive protein and cardiac function indexes were compared between the two groups.Results:After treatment,the levels of N-terminal brain natriuretic peptide precursor and C-reactive protein in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the left ventricular ejection fraction,left ventricular enddiastolic diameter,left ventricular end-systolic diameter and blood volume per stroke in the observation group were better than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the heart rate and blood pressure in the observation group were significantly lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:Valsartan hydrochlorothiazide tablets in the treatment of essential hypertension complicated with chronic cardiac insufficiency can rapidly reduce the levels of N-terminal brain natriuretic peptide precursor and C-reactive protein,and improve the cardiac function,with significant efficacy,it is worthy of promotion.