养正合剂辅助治疗直肠癌化疗患者厌食的临床研究

Clinical Study of Yangzheng Mixture Adjuvant Treatment of Anorexia in Patients with Rectal Cancer Chemotherapy

目的:探讨养正合剂辅助治疗直肠癌化疗患者厌食的临床效果。方法:选取2019年2月-2021年2月在黑龙江省佳木斯市肿瘤医院肿瘤五科接受直肠癌化疗的患者60例,按照数字随机法分为对照组和试验组,各30例。对照组患者采用奥沙利铂联合卡培他滨方案化疗,试验组在对照组治疗基础上加用养正合剂。评估两组患者治疗效果、生活质量满意度、不良反应、人体指标和营养指标情况。结果:试验组患者治疗总有效率高于对照组,差异有统计学意义(P<0.05)。试验组患者生活质量满意度高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者体重、体重指数和总蛋白、白蛋白含量均有所提高,与治疗前比较,差异有统计学意义(P<0.05);治疗后试验组体重、体重指数、总蛋白、白蛋白、转铁蛋白水平均高于对照组,差异有统计学意义(P<0.05)。对照组不良反应发生率高于试验组,差异有统计学意义(P<0.05)。结论:养正合剂可提高直肠癌化疗效果,改善化疗厌食患者的生活质量和营养状况,降低化疗药物不良反应发生率,值得临床推广。

Objective:To explore the clinical effect of Yangzheng mixture adjuvant treatment of anorexia in patients with rectalcancer chemotherapy.Methods:Sixty patients receiving chemotherapy for rectal cancer in No.5 Department of Oncology,JiamusiTumor Hospital from February 2019 to February 2021 were selected and divided into control group and experimental groupaccording to the numerical random method,with 30 cases in each group.Patients in the control group received oxaliplatincombined with capecitabine chemotherapy,and patients in the experimental group received Yangzheng mixture on the basis oftreatment in the control group.The therapeutic effect,quality of life satisfaction,adverse reactions,human indicators andnutritional indicators were evaluated in two groups.Results:The total effective rate of patients in the experimental group washigher than that in the control group,and the difference was statistically significant(P<0.05).The quality of life satisfaction of thepatients in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the body weight,body mass index,total protein and albumin contents of the two groups were increased,andthe difference was statistically significant compared with before treatment(P<0.05).After treatment,the levels of body weight,body mass index,total protein,albumin,and transferrin in the experimental group were higher than those in the control group,andthe difference was statistically significant(P<0.05).The incidence of adverse reactions in the control group was higher than that inthe experimental group,and the difference was statistically significant(P<0.05).Conclusion:Yangzheng mixture can improve thecurative effect of rectal cancer chemotherapy,improve the quality of life and nutritional status of patients with chemotherapyanorexia,reduce the incidence of adverse reactions of chemotherapy drugs,and deserve clinical promotion.