超声引导下麦默通乳腺微创旋切术治疗乳腺良性肿瘤疗效及对乳房外观美观度与肿瘤标志物水平影响的研究

Curative effect of ultrasound-guided Mammotome minimally invasive breast resection on breast benign tumors and the influences of that on the beautiful degree of breast appearance and the levels of tumor markers

目的:观察超声引导下麦默通乳腺微创旋切术治疗乳腺良性肿瘤疗效及对患者乳房外观美观度及肿瘤标志物癌胚抗原(CEA)、糖链抗原125(CA125)水平的影响。方法:选取医院收治的160例青年乳腺良性肿瘤患者,按照随机数表法将其分为微创手术组和传统手术组,每组80例。微创手术组行超声引导下麦默通乳腺微创旋切术,传统手术组行开放手术。对比两组手术情况、并发症及术后1年乳房外观美观度,以及与术前、术后3 d、术后1周时的血清CEA和CA125水平。结果:微创手术组手术时间、瘢痕长度及住院时间较传统手术组短,术后当日疼痛程度视觉模拟量表(VAS)评分、术中出血量均低于传统手术组,差异有统计学意义(t=13.218,t=10.431,t=16.747,t=31.081,t=10.294;P<0.05);微创手术组并发症发生率低于传统手术组,差异有统计学意义(x^(2)=9.014,P<0.05);微创手术组术后3 d、术后1周时的血清CEA和CA125水平低于术前,差异有统计学意义(t_(3 d)=12.456,t=10.389;t_(1周)=7.528,t=8.634;P<0.05),但两组间比较,差异无统计学意义;微创手术组术后1年乳房外观美观度优于传统手术组,差异有统计学意义(Z=4.100,P<0.05)。结论:超声引导下麦默通乳腺微创旋切术治疗青年乳腺良性肿瘤具有精准、微创的特点,提高乳房外观美观度,同时对患者血清肿瘤标志物改善无不良影响。

Objective:To observe the curative effect of ultrasound-guided Mammotome minimally invasive breast resection on breast tumors and the influences of that on the beautiful degree of breast appearance and the levels of carcinoembryonic antigen(CEA) and carbohydrate antigen 125(CA125).Methods:160 young patients with breast benign tumors who admitted to hospital were selected.And they were divided into minimally invasive surgery group(n=80) and conventional surgery group(n=80) by random number table.The minimally invasive surgery group underwent ultrasound-guided Mammotome minimally invasive breast resection,and the conventional surgery group underwent opened surgery.The surgical conditions,complications and the beautiful degree of the appearance of breasts at 1 year after surgery,as well as the CEA and CA125 levels before surgery,at the 3th day and the 1th week after surgery were compared between the two groups.Results:The surgical time,scar length and hospital stays of minimally invasive surgery group were significantly shorter than those of conventional surgery group,and the visual analogue scale(VAS) scores on that day of surgery and intraoperative blood loss of minimally invasive surgery group were significantly lower than those of conventional surgery group(t=13.218,t=10.431,t=16.747,t=31.081,t=10.294,P<0.05).The incidence of complication of former was significantly lower than that of conventional surgery group(x^(2)=9.014,P<0.05).Serum CEA and CA125 levels at the 3th day and the 1th week after surgery were significantly lower than those before surgery(t_(3d)=12.456,t=10.389,t_(1th week)=7.528,t=8.634,P<0.05),but there was no significant difference between the two groups.The beautiful degree of the appearance of breasts of minimally invasive surgery group was significantly better than that of conventional surgery group at the 1th year after surgery(Z=4.100,P<0.05).Conclusion:Ultrasound-guided Mammotome minimally invasive breast resection has the characteristics of precision and minimally invasiveness in treating young patients with benign breast tumors,which can improve the beautiful degree of the appearance of breasts.At the same time,it doesn’t have adverse effect on the improvement of serum tumor markers of patients.