计算机认知矫正治疗技术在慢性精神分裂症患者认知功能缺陷治疗中的应用效果

Application Effect of Computerized Cognitive Remediation Therapy in the Treatment of Cognitive Impairment in Patients with Chronic Schizophrenia

目的:探讨计算机认知矫正治疗技术(CCRT)在慢性精神分裂症患者认知功能缺陷治疗中的应用效果。方法:选取2020年1月至2021年3月上海交通大学医学院附属精神卫生中心收治的200例慢性精神分裂症患者作为研究对象,采用随机数字表法分为两组:对照组100例患者采用常规药物治疗,观察组100例患者采用CCRT联合基础药物治疗。观察两组患者治疗前后计算机成套认知测验系统(ACCT)评分、MATRICS共识认知成套测验(MCCB)评分的变化;统计两组患者不良事件发生情况。结果:两组患者治疗前ACCT评分差异无统计学意义(P>0.05),两组患者治疗1个月后和治疗3个月后的ACCT评分较治疗前逐渐升高,且观察组明显高于对照组,差异有统计学意义(P<0.05)。两组患者治疗前MCCB评分中连线测验、符号编码、语义流畅性、持续操作测验、数字序列和空间广度、言语记忆、视觉记忆、迷宫测验、情绪管理测验的分数差异无统计学意义(P>0.05),两组患者治疗1个月后和治疗3个月后上述项目的评分均逐渐升高,且观察组明显高于对照组,差异均有统计学意义(P<0.05)。观察组的不良事件发生率低于对照组(P<0.05)。结论:通过系统的CCRT治疗可以显著改善慢性精神分裂症患者的认知缺陷,增进患者社会活动水平,提高患者社会功能,减少不良事件发生。

Objective:To explore the effect of computerized cognitive remediation therapy(CCRT)in the treatment of cognitive impairment in patients with chronic schizophrenia.Methods:200 patients with chronic schizophrenia who were treated in the mental health center affiliated to medical college of Shanghai Jiaotong University from January 2020 to March 2021 were selected as the research objects,and they were randomly divided into two groups:100 patients in the control group were treated with conventional drugs,and 100 patients in the observation group were treated with CCRT combined with basic drugs.The changes of computer cognitive test(ACCT)score and MATRICS consensus cognitive test(MCCB)score in the two groups were observed before and after treatment.The adverse events in the two groups were counted.Results:There was no significant difference in ACCT score between the two groups before treatment(P>0.05).The ACCT score of the two groups at 1 month and 3 months after treatment were gradually higher than that before treatment,and the observation group was significantly higher than that of the control group,the differences were statistically significant(P<0.05).There were no significant differences in the MCCB scores of connection test,symbol coding,speech fluency,continuous performance test,number sequence and spatial breadth,verbal memory,visual memory,maze test and emotion management test between the two groups before treatment(P>0.05).The scores of the above items in the two groups increased gradually at 1 month and 3 months after treatment,and the scores in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse events in the observation group was lower than that in the control group(P<0.05).Conclusion:Systematic CCRT treatment can significantly improve the cognitive impairment of patients with chronic schizophrenia,improve the level of social activities,improve the social function and reduce the occurrence of adverse events.