子宫内膜异位症对子宫内膜容受性的影响新进展

New progress in the influence of endometriosis on endometrial receptivity

胚胎植入失败是目前辅助生殖技术面临的难题,而子宫内膜容受性又是影响胚胎成功着床的关键因素。尽管目前对子宫内膜在健康和疾病方面的研究取得了很大的进展,子宫内膜容受性的调控机制仍不完全清楚。许多临床证据表明子宫内膜异位症是育龄女性不孕的主要原因之一,然而子宫内膜异位症通过影响子宫内膜容受性并导致不孕的机理仍有待进一步阐述。本文将对国内外有关妊娠早期子宫内膜异位症对子宫内膜容受性影响的最新进展作一简要概述。

Failure in embryo implantation is a common issue in assisted reproduction technology,and establishment of endometrial receptivity plays a critical role in the process of embryo implantation.Although it was extensively studied in the endometrial physiology,the molecular mechanism underlying regulation of endometrial receptivity remains elusive.Ample clinical evidence suggests that endometriosis is closely associated with female infertility in reproductive age,it is still unclear how endometriosis adversely affects endometrial receptivity that leads to failure in embryo implantation.This literature review is mainly focusing on recent progress on adverse effect of the endometriosis on endometrial receptivity during early pregnancy.