倍他司汀联合血塞通对后循环缺血性眩晕患者血液流变学、椎-基底动脉血流动力学及生化指标的影响

The effect of betahistine combined with Xuesaitong on hemorheology, vertebrobasilar hemodynamics and biochemical indexes in patients with posterior circulation ischemic vertigo

目的 分析倍他司汀联合血塞通对后循环缺血性眩晕患者血液流变学、椎-基底动脉血流动力学及生化指标的影响。方法 选取我科105例住院治疗后循环缺血性眩晕患者,对照组52例给予常规治疗和盐酸倍他司汀治疗,观察组53例在对照组的基础上联合血塞通治疗,观察两组患者的临床疗效,血液流变学指标,椎-基底动脉血流动力学,生化指标,药物安全性。结果 观察组总有效率高于对照组(P<0.05);血液流变学指标PV、WBV、FIB均低于对照组(P<0.05);椎基底动脉血流LVA、RVA、BA水平高于对照组(P<0.05),RI低于对照组(P<0.05);生化指标ET-1水平低于对照组(P<0.05),CGRP水平高于对照组(P<0.05);药物安全性不具有统计学意义(P>0.05)。结论 倍他司汀联合血塞通治疗缺血性眩晕患者可调节ET-1、CGRP因子,降低血液黏度指标水平,恢复椎-基底动脉血流动力,提高临床疗效,安全性较高。

Objective To analyze the effects of Betahistine combined with Xuesaitong on the hemorheology,Hemodynamics and biochemical parameters in patients with posterior circulation ischemic vertigo.Methods 105 patients with circulatory ischemic vertigo after hospitalization in our department were selected,52 patients in the control group were given routine treatment and Betahistinehydrochloride treatment,53 patients in the observation group were given Xuesaitong treatment on the basis of the control group,the clinical efficacy of the two groups were observed,hemorheology,vertebrobasilar Hemodynamics,biochemical markers,drug safety.Results The total effective rate of the observation group was higher than that of the control group(P<0.05),and the hemorheology indexes of PV,WBV and FIB were lower than that of the control group(P<0.05)The levels of Lva,Rva,BA in the vertebrobasilar artery were higher than those in the control group(P<0.05),Ri were lower than those in the control group(P<0.05),the levels of ET-1 and CGRP were lower than those in the control group(P<0.05),and the drug safety was not statistically significant(P<0.05).Conclusion Betahistine combined with Xuesaitong can regulate ET-1 and CGRP factor,decrease blood viscosity index,restore blood flow of vertebrobasilar artery,improve clinical efficacy and safety.