甲磺酸阿帕替尼联合DEB-TACE治疗中晚期肝细胞癌的效果及其对血生化指标、生存期及生存率的影响

The effect of apatinib mesylate combined with DEB-TACE in the treatment of advanced hepatocellular carcinoma and its influence on blood biochemical indexes, survival period and survival rate

目的 探讨甲磺酸阿帕替尼联合DEB-TACE治疗中晚期肝细胞癌的效果及其对血生化指标、生存期及生存率的影响。方法 选取我科2017年1月至2018年10月期间101例病人。通过随机数字表法分为对照组和观察组,对照组患者给予DEB-TACE治疗和表柔比星30mg和超液化碘油混合乳剂4ml,观察组在对照组的基础上给予甲磺酸阿帕替尼片850mg。观察两组患者治疗中晚期肝细胞癌的效果及其血生化指标。结果 观察组的缓解率41.18%、控制率62.75%、半年存活率和一年存活率较对照组高(P<0.05);治疗后患者甲胎蛋白(AFP)、乳酸脱氢酶(LDH)、总胆红素(TBIL)、谷丙转胺酶(ALT)较治疗前低,且观察组的AFP、LDH、TBIL、ALT较对照组低(P<0.05);两组患者不良反应无统计学意义(P>0.05)。结论 DEB-TACE治疗中晚期肝细胞癌患者临床效果好,可以阻止肿瘤血管生长,从而杀死癌细胞,延长患者生存时间,提升生存率,安全性高。

Objective To investigate the effect of apatinib mesylate combined with DEB-TACE in the treatment of advanced hepatocellular carcinoma and its influence on blood biochemical indexes,survival time and survival rate.Methods 101 patients in our department were divided into the control group and the observation group by random number table method.The control group was treated with DEB-TACE treatment and epirubicin 30 mg and super-liquid lipiodol mixed emulsion 4 ml.The observation group was in the control group.On the basis of the group,850 mg of apatinib mesylate tablets were given.Observe the treatment effect of two groups of patients with advanced hepatocellular carcinoma and their blood biochemical indexes.Results The remission rate of the observation group was 41.18%,the control rate was 62.75%,the half-year survival rate and the one-year survival rate were higher than those of the control group(P<0.05);AFP,LDH,TBIL,and ALT in the blood biochemical indexes of the patients after treatment were higher than those of the treatment group The former was low,and the AFP,LDH,TBIL and ALT of the observation group were lower than those of the control group(P<0.05);the adverse reactions of the two groups were not statistically significant(P>0.05).Conclusion DEB-TACE has a good clinical effect in the treatment of patients with advanced hepatocellular carcinoma.It can prevent the growth of tumor blood vessels,thereby killing cancer cells,prolonging the survival time of patients,improving survival rate,and high safety.