术前TFF1、HSP70、ASPH与原发性肝癌患者手术切除术后早期复发的关系研究

Study on the Relationship between Preoperative TFF1,HSP70,ASPH and Early Recurrence of Patients with Primary Liver Cancer after Surgical Resection

目的:研究术前三叶因子1(TFF1)、热休克蛋白70(HSP70)、天冬氨酸-天冬酰胺β羟化酶(ASPH)与原发性肝癌(PHC)患者手术切除术后早期复发的关系。方法:选取2018年1月~2019年12月我院收治的83例PHC患者,均行手术切除治疗,术后均随访2年,根据是否复发分为复发组49例以及未复发组34例。比较两组术前TFF1、HSP70、ASPH水平差异,收集患者基线资料,采用多因素Logistic回归分析PHC患者手术切除术后早期复发的危险因素,采用受试者工作特征(ROC)曲线分析术前TFF1、HSP70、ASPH水平预测PHC患者手术切除术后早期复发的效能。结果:复发组术前TFF1、HSP70、ASPH水平均高于未复发组(P<0.05)。复发组肿瘤直径≥5 cm、肿瘤数目为多发、有血管侵犯的患者比例高于未复发组(P<0.05)。多因素Logistic回归分析结果显示:肿瘤直径≥5 cm、多发肿瘤、血管侵犯及术前TFF1、HSP70、ASPH高水平是PHC患者手术切除术后早期复发的危险因素(均OR>1,P<0.05)。ROC曲线分析结果显示:术前TFF1、HSP70、ASPH联合检测预测PHC患者手术切除术后早期复发的曲线下面积为0.815,明显高于上述三项指标单独检测的0.704、0.713、0.707。结论:术前TFF1、HSP70、ASPH与PHC患者手术切除术后早期复发密切相关,联合检测三项指标水平可能有助于预测PHC患者手术切除术后早期复发。

Objective:To study the relationship between preoperative trefoil factor 1(TFF1),heat shock protein 70(HSP70),aspartate-asparagineβhydroxylase(ASPH)and early recurrence of patients with primary liver cancer(PHC)surgical resection.Methods:83 patients with PHC who were treated in our hospital from January 2018 to December 2019 were selected,all patients underwent surgical resection,and all patients were followed up for 2 years,according to whether they had recurrence,they were divided into 49 cases in the recurrence group and 34 cases in the non-recurrence group.The preoperative TFF1,HSP70 and ASPH levels differences of the two groups were compared,the baseline data of patients were collected,and the influencing factors of early recurrence of patients with PHC after surgical resection were analyzed by multivariate Logistic regression.Receiver operating characteristic(ROC)curve was used to analyze the efficacy of preoperative TFF1,HSP70 and ASPH levels in predicting early recurrence of patients with PHC after surgical resection.Results:The preoperative TFF1,HSP70 and ASPH levels in the recurrence group were higher than those in the non-recurrence group(all P<0.05).The proportion of patients with tumor diameter≥5 cm,the number of tumors was multiple and had vascular invasion in the recurrence group were higher than those in the non-recurrence group(P<0.05).Multivariate Logistic regression analysis showed that tumor diameter≥5 cm,multiple tumors,vascular invasion and high preoperative TFF1,HSP70 and ASPH levels were risk factors for early recurrence in patients with PHC after surgical resection(all OR>1,P<0.05).ROC curve analysis showed that the area under the curve of preoperative TFF1,HSP70 and ASPH combined detection in predicting early recurrence of patients with PHC after surgical resection was 0.815,which was significantly higher than 0.704,0.713 and 0.707 of the above three indicators alone.Conclusions:Preoperative TFF1,HSP70 and ASPH are closely correlated with early recurrence in patients with PHC after surgical resection.Combined detection of the levels of the three indicators may help predict early recurrence in patients with PHC after surgical resection.