桂枝附子汤联合太极拳治疗寒湿型坐骨神经痛的临床疗效及对相关理化指标水平的影响

Clinical Efficacy of Guizhi Fuzi Decoction Combined with Tai Chi in the Treatment of Cold-damp Type Sciatica and Its Influence on the Levels of Related Physical and Chemical Indicators

目的:探讨与分析桂枝附子汤联合太极拳治疗寒湿型坐骨神经痛的临床疗效及对相关理化指标水平的影响。方法:选择2017年12月至2020年12月在本院诊治的88例寒湿型坐骨神经痛患者作为研究对象,根据随机1:1分配法把患者分为联合组与对照组,各44例。所有患者均给予药物治疗,对照组给予太极拳治疗,联合组以对照组为基础上给予桂枝附子汤治疗,两组均治疗观察2周,记录两组的临床疗效及对相关理化指标水平变化情况。结果:联合组治疗后的总有效率为97.7%,对照组为84.1%,联合组高于对照组(P<0.05)。与治疗前相比,两组治疗后的JOA评分升高,联合组高于对照组(P<0.05)。两组治疗后的腓肠神经运动神经传导速度(MCV)与腓肠神经感觉神经传导速度(SCV)高于治疗前,联合组高于对照组(P<0.05)。两组治疗后的血清5-羟色胺(5-HT)和P物质(SP)含量低于治疗前,联合组较对照组低(P<0.05)。联合组不良反应发生率为6.8%,低于对照组的31.8%(P<0.05)。结论:桂枝附子汤联合太极拳治疗寒湿型坐骨神经痛能抑制血清5-HT与SP的释放,改善患者的神经传导速度,可提高患者的腰椎功能与总体疗效,还可减少不良反应。

Objective:To explore and analysis the clinical efficacy of Guizhi Fuzi Decoction combined with Tai Chi in the treatment of cold-damp type sciatica and its influence on the levels of related physical and chemical indicators.Methods:From December 2017 to December 2020,A total of 88 patients with cold-damp sciatica who were diagnosed and treated in our hospital were selected as the research objects.All the patients were divided into the joint group and the matched group with 44 patients in each group accorded to the random 1:1 allocation method.The matched group were given Tai Chi treatment,and the joint group were given Guizhi Fuzi Decoction on the basis of the treatment of the matched group.The clinical curative effect and the changes of related physical and chemical indexes were recorded in the two groups.Results:The total effective rates after treatment in the combined group were 97.7%,which were higher than 84.1%in the matched group(P<0.05).The JOA scores of the two groups after treatment were higher than those before treatment,and the joint group were different with that of the matched group(P<0.05).The motor nerve conduction velocity(MCV)and sensory nerve conduction velocity(SCV)of sural nerve were higher in the combined group than in the matched group after treatment(P<0.05).The serum levels of 5-hydroxytryptamine(5-HT)and Substance P(SP)in the two groups after treatment were different with before treatment,and those in the joint group were lower than those in the matched group(P<0.05).The incidence in the joint group were 6.8%,which were lower than 31.8%in the matched group(P<0.05).Conclusion:Guizhi Fuzi Decoction combined with Taijiquan in the treatment of cold-damp type sciatica can inhibit the release of serum 5-HT and SP,improve the nerve conduction velocity of patients,improve the lumbar spine function and overall curative effect,and reduce the occurrence of adverse reactions.