B超配合金匮温经汤治疗卵巢早衰患者疗效及其生殖功能、血清雌激素的影响

The Effect of B-ultrasound Combined with Jinkui Wenjing Decoction in the Treatment of Patients with Premature Ovarian Failure and the Effect of Reproductive Function and Serum Estrogen

目的:探讨B超配合金匮温经汤治疗卵巢早衰患者疗效及其生殖功能、血清雌激素的影响。方法:选择2018年5月到2020年12月选择在本院诊治的96例卵巢早衰患者作为研究对象,根据1:1随机数字表法把患者分为研究组与对照组各48例。对照组给予激素替代疗法治疗,研究组在对照组治疗的基础上给予金匮温经汤治疗,所以患者在治疗前后进行B超观察。结果:治疗后研究组的总有效率为97.9%,高于对照组的85.4%(P<0.05),两组在治疗期间无严重不良反应发生。两组治疗后的血清卵泡生成激素(FSH)、黄体生成激素(LH)含量都低于治疗前,研究组低于对照组(P<0.05);血清雌二醇(E2)含量都高于治疗前,研究组高于对照组(P<0.05)。两组治疗后的改良Kupperman评分都低于治疗前,研究组低于对照组(P<0.05)。两组治疗后的卵泡数目与卵泡大小都高于治疗前,研究组高于对照组(P<0.05)。结论:金匮温经汤治疗卵巢早衰患者能提高治疗效果,改善患者的血清雌激素分泌与生殖功能,也有利于抑制炎症因子的表达,与B超配合使用可反映患者的卵泡情况,更有利于指导临床治疗与预后预测。

Objective:To investigate the effect of B-ultrasound combined with Jinkui Wenjing Decoction in the treatment of pa-tients with premature ovarian failure and the effects of reproductive function and serum estrogen.Methods:From May 2018 to December 2020,96 cases of patients with premature ovarian failure who were diagnosed and treated in this hospital were selected as the research objects.All the cases were divided into the study group and the control group with 48 cases each groups accorded to the 1:1 random number table method.The control group were treated with hormone replacement therapy,and the study group were treated with Jinkui Wenjing Decoction on the basis of the treatment of the control group,so the patients underwent B-ultrasound observation before and after treatment.Results:After treatment,the total effective rate of the study group were 97.9%,which were higher than 85.4%of the control group(P<0.05).There were no serious adverse reactions in the two groups during the treatment.The serum Follicle-stimulating Hormone(FSH)and Luteinising Hormone(LH)levels after treatment in the two groups were lower than before treatment(P<0.05),and the study group were lower than the control group(P<0.05).The erum estradiol(E2)levels were higher than before treatment,and the study group were higher than the control group(P<0.05).The modified Kupperman scores of the two groups after treatment were lower than those before treatment,and the study group were lower than the control group(P<0.05).The number and size of follicles after treatment in the two groups were higher than before treatment(P<0.05),and the study group were higher than that in the control group(P<0.05).Conclusion:Jinkui Wenjing Decoction can improve the treatment effect of patients with premature ovarian failure,improve the patient's serum estrogen secretion and reproductive function,and also help to inhibit the expression of inflammatory factors.The use of combined with B-ultrasound can reflect the patient's follicular condition,and more Conducive to guiding clinical treatment and prognosis prediction.